Patient demographics, mutational signatures, and tumor microenvironment factors were assessed, with particular attention to smoking status and concomitant alterations in KRAS and TP53. Treatment outcomes were analyzed by time under treatment as a surrogate measure of TKI efficacy. Uncommon EGFR mutations, ...
can be explained by the absence of glucosyl groups. Overall, our data propose Kaempferol as a potential chemotherapeutic agent to be used alone or in combination with 5-FU to overcome colon cancer drug resistance.
Firstly, as explained above, it plays a pivotal role in improving the photon density of trapped light, thereby contributing to an increased Raman scattering effect. Secondly, PDDA's electron donating amine groups strongly interact with electron deficient NO2 groups of DNT, a factor responsible for...
No matter whether we assume that all arthropod ocelli are phylogenetically homologous or whether we limit this assumption to the ocelli of hexapods or the ones of insects, a gap between the time of tissue furcation and opsin gene duplication remains. Similar findings were made in a previous stud...
This TP change can be explained by a change in food preferences or food selection capabilities throughout ontogeny. During early youth, A. islandica feeds on particles collected from the seabed, almost like a deposit feeder (Molero et al., 2011), while older specimens with a larger siphon ...
(2012) also mentioned that bulk isotope ratios of nitrogen in crab (13.7–14.7‰; mussels: 9.7–11.2‰) explained their role as a benthic carnivore (trophic level = 3) in this ecosystem. The discrepancy in the TPs of these top predators suggests that their diets are derived from different ...
In the 2Br system, in addition to the semiconducting behavior below 50 K, Shubnikov-de Hass oscillations with two different frequencies have been observed and have been considered as a prediction of the existence of two FSs which is probably explained with a 2a × 2b lattice transformation of ...
This inconsistency has yet to be explained; δ15N values for arginine, a nitrogen-rich AA that is not commonly measured in nitrogen-focused CSIA studies, would potentially be informative. Indeed, for all CSIA studies, researchers should bear in mind that dynamics of carbon, nitrogen, and ...
A research group reported that neurogenesis was increased in human AD patients, which was explained by the presence of a self-compensatory mechanism to replace the degenerated neurons [80,101]. However, the number of these newly born neurons is small and consequently they are unlikely to replace...