By default, 50 TFs are reported and plotted as a bar-chart in terms of their normalised enrichment score (NES, from -1 to 1). This number is generally a trade-off between coverage and noise which can be examined by adjusting the slider and viewing the NES plot, which updates ...
a| The chart shows the distributions of the measured aqueous solubility of ∼2,000 compounds synthesized at AstraZeneca's Södertälje site in the early 2000s (good compounds have a solubility higher than 100 μM; medium compounds have a solubility of 10–100 μM; poor compounds have a ...
Increas- ing the time limit or number of cores hence allows the solver to generate more networks, which may be required if no optimal solutions are found. Following DoRothEA analysis, the resulting normalised enrichment scores (NES) for each TF are displayed as a bar chart (Fig. 6) and...