The clique level [19] of protein i is defined as the maximal clique containing i. Here, only cliques with sizes between 3 and 10 proteins were taken into consideration. Sequence primary structural features such as protein length, cysteine count, amino acid occurrence, average cysteine position, ...
A20 (also known as TNFAIP3) is a potent anti-inflammatory signalling molecule that restricts multiple intracellular signalling cascades. Recent studies in three general areas have converged to highlight the clinical and biological importance of A20. First, human genetic studies have strongly linked pol...
d, The Cas7 molecules (blue) found in the asymmetric unit of the Cas7:AcrIF25 crystal are depicted as ribbons and overlaid. Also overlaid and displayed as a ribbon is a Cas7 molecule (red) found within a Csy complex (PDB ID: 6B45; molecule F). Cas7 residues 55 to 75 were not...
(including elongation and termination factors; not represented in the scheme) can undergo one of three different fates (a–c). (a) They emerge unmodified from the transcription cycle and can be reused as such on the same or on a new template molecule for a new cycle. (b) They...
In anaerobic conditions the final electron acceptor can be sulfur or sulfate, but with the advent of an O 2 gas-containing atmosphere on the Earth's surface and waters, life adapted to use the highly electronegative O 2 molecule as the final electron acceptor. This process relies on the ...
the mouse and the human ortholog, respectively). The Arp1 rod is built of eight Arp1 molecules forming a short actin-like filament, probably one β-actin molecule, and the conventional actin capping proteins Capα and Capβ, which are located at the barbed-end of the mini-filament. The ...
Twelve samples of leaf litter containing animals and eggs morphologically attributable toP. richtersiwere collected in different Italian localities, whereas two samples were collected from the type locality (Kinnacorra, Clare Island, Mayo county; Ireland) (Table1; Fig.1). In the type locality, spe...
Kind Code: A1 Abstract: The present invention provides a chaperonin-target protein complex and a method of producing the same, and a method of stabilizing the target protein, a method of immobilizing the target protein, a method of analyzing the structure of the target protein, a sustained-re...
Cas6 recognizes a short RNA loop and cuts the molecule directly downstream and, as shown by Tsai et al.54, this endoribonuclease can be harnessed to process a single RNA molecule into several individual gRNAs (Fig. 2C). This strategy offers the advantage that a single promoter is used to ...
The largest subunit of the RQT complex, Slh1, belongs to a family of ATP-dependent Ski2-like RNA helicases and contains two RecA-like helicase cassettes (Fig. 2a and Supplementary Fig. 2a), so we first analyzed a single molecule of Slh1. In the HS-AFM images of Slh1, we found two...