Taken together, our results indicate that the rigidity of collagen gel controls expression of focal adhesion complex proteins, which is mediated by a2b1 integrin, but not DDR1.YangKao Wang
Indeed, in addition to the accumulation of well-characterized autophagy substrates, we also noticed an increase in endocytic cargos like IGF1R, EGFR and B1 integrin and slowed kinetics of EGFR degradation. However, we cannot exclude any direct chaperoning effect on CCT on these proteins which may...
Patients with IDH-wild-type glioblastomas have a poor five-year survival rate along with limited treatment efficacy due to immune cell (glioma-associated microglia and macrophages) infiltration promoting tumour growth and resistance. To enhance therapeut
Thoracic aortic aneurysm (TAA) is a serious condition that affects the aorta, characterized by the dilation of its first segment. The causes of TAA (e.g., age, hypertension, genetic syndromes) are heterogeneous and contribute to the weakening of the aort
Integrin α-2 1.8880 0.0464 10 kDa Heat shock protein, mitochondrial 2.0701 0.0346 Transitional endoplasmic reticulum ATPase 2.4210 0.0003 60 kDa Heat shock protein, mitochondrial 3.2810 0.0170 Response to DNA damage stimulus Asparagine synthetase (glutamine-hydrolyzing) 1.8030 0.0026 78 kDa Glucose-regulate...
Furthermore, the different wound healing performances of T47D cells, on coated and non-coated wells, reaffirm the existence of crosstalk between integrin signaling and the CmPn signaling network. Differential effects of steroid hormones on cell invasion of Luminal-A breast cancer cells Utilizing ...
The β4 integrin, also part of the laminin binding Integrins, are known to mediate hemidesmosome assembly and promote Raf-ERK and Rac-JNK signaling; mice deficient in the β4 integrin C-terminus (cytoplasmic tail) had reduced angiogenic response to VEGF, confirming the essential role of β4 ...
all PTB domains from 17 different proteins were capable to bind to a subset of type A motif-containing integrin cytoplasmic tails in an in vitro binding assay, whereas only a handful of these PTB proteins have been characterized to have bona fide effects on integrin-mediated cell adhesion events...
(insets a1, a2, b1, c1, c2) are presented. IN-2 colocalized with Rab7 or CD63, but not Lamp1 in NEIs (yellow and magenta arrow, respectively).dNoninfected VAP-A-GFP-expressing HeLa cells were Rab7 and Lamp1 immunolabeled. Single transverse section of a NEI is shown with the merge...
6326403 Diacylhydrazine derivatives as integrin inhibitors 2001-12-04 Hölzemann et al. 6300488 Modified lepidopteran receptors and hybrid multifunctional proteins for use in transcription and regulation of transgene expression 2001-10-09 Gage et al. 6281330 Multimeric forms of members of the steroid/...