Activation of the complement system and resulting opsonisation with Ob are key events of the innate immune defense against infections. However, a wide variety of bacterial pathogens subvert complement attack by binding host complement inhibitors such as C4b-binding protein, factor H and vitronectin, ...
NS1 binds to and recruits a complement regulatory protein, factor H, and the ability of NS1 to interact with factor H correlates with its ability to impair complement activation and to suppress deposition of C3 and formation of membrane attack complexes on infected cells....
Here we identify an African trypanosome receptor for mammalian factor H, a negative regulator of the alternative pathway. Structural studies show how the receptor binds ligand, leaving inhibitory domains of factor H free to inactivate complement C3b deposited on the trypanosome surface. Receptor ...
C3b can interact with regulatory protein factor H to promote inactivation by protease factor I, leading to the loss of a small fragment from the a′ chain, C3f, and the formation of the inactive fragment iC3b (b). There are receptors for iC3b on phagocytes and dendritic cells, such as...
Factor H (FH) is a natural inhibitor of the alternative pathway (AP) of complement (C) activation, an abundant protein in blood whose reduced level has been associated with proneness for increased C activation. There are also 5 FH-related proteins (FHR), which have different impacts on C ...
Factor H is a regulatory protein of the alternative pathway of complement activation. The liver is the major site of synthesis. We have used the Hep3b human liver cell line as a model for examining its regulation by interferon-γ (IFN-γ). The maximal response was achieved at 50 U/ml of...
Staphylococcus aureus Surface Protein SdrE Binds Complement Regulator Factor H as an Immune Evasion Tactic Similar to other highly successful invasive bacterial pathogens,Staphylococcus aureusrecruits the complement regulatory protein factor H (fH) to its surfac... JA Sharp,CG Echague,PS Hair,... -...
Location of the complement factor H binding site on streptococcal M6 protein. The surface M protein of group A streptococci binds factor H, a regulatory protein of the alternative complement pathway, which may contribute to the antip... VA Fischetti,RD Horstmann,V Pancholi - 《Infection & Immun...
Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation.doi:10.4049/jimmunol.1403121The physiological roles of the factor H (FH)-related proteins are controversial and poorly understood. Based on genetic studies, FH-related protein 5 (CF...
Binding of the complement regulatory proteins factor H, factor H-like protein 1 (FHL-1), C4b-binding protein (C4BP), or CD46 is a crucial step in the pathogenesis of these infections. M protein is the GAS protein that generally mediates these interactions. However, a detailed analysis of ...