Complement Factor H (FH) is an abundant, non-enzymic plasma/serum glycoprotein, which has a major role in regulating activation of the complement system. It can be purified from human plasma/serum by affinity chromatography, using a monoclonal anti-FH antibody as ligand. Other affinity ...
英文名称: Human Complement factor H ELISA KIT 用途: 补体因子 H 是分子量约为 155kDa 的糖蛋白,能够为补体级联反应的替代途径提供关键负调控作用,该蛋白由 Kupffer 细胞、肝细胞、血管内皮细胞和血小板分泌产生,血清中浓度较高。补体因子 H 由 20 个短保守重复序列(short consensus repeats,SCR)组成,每个序列...
Complement factor H (fH) regulates activation of the alternative pathway of C, reducing the amount of C3b deposited on sialic acid-rich surfaces. Heparin binding has been used as a model for examining the sialic acid-binding characteristics of fH. We have previously shown that of the 20 short...
In humans, there are also five factor H-related (FHR) proteins, whose function is poorly characterized. While data indicate complement inhibiting activity for some of the FHRs, there is increasing evidence that FHRs have an opposite role compared with factor H and FHL-1, namely, they enhance...
全称:beta-1H; H factor 2 (complement); age-related maculopathy susceptibility 1; H factor 1 (complement) CFH 分子靶点综述 补体因子H,又称H因子1和CFH,是一种含唾液酸的糖蛋白,在调节补体介导的免疫系统中起着不可或缺的作用,该免疫系统参与微生物防御、免疫复合物处理和细胞程序性死亡。CFH作为补体系统...
Author(s): Dinasarapu, Ashok Reddy; Chandrasekhar, Anjana; Jozsi, Mihaly; Subramaniam, Shankar | Abstract: Complement factor H (fH) is a single chain plasma glycoprotein (approximately 150 kDa in size), with 20 domains termed complement control protein (CCP) domains or short consensus repeats ...
OBJECTIVE: Variations in complement factor H, which down-regulates the activity of the alternative complement pathway, have been associated with different vascular disorders. Here we examine whether factor H variation is involved in the etiology of preeclampsia. METHODS: We studied 110 women with ...
特异性可检测样本中的人补体因子H,且与其类似物无明显交叉反应。 SpecificityThis kit recognizes Human CFH(Complement Factor H) in samples. No significant cross-reactivity or interference between Human CFH(Complement Factor H) and analogues was observed. ...
Factor H is a serum protein acting as an inhibitor in the complement activation system. I activates the C3/C5 convertase by dissociating its subunits and also acts as a cofactor for the enzyme activity of Factor I. 仅用于科研。不用于诊断过程。未经明确授权不得转售。
complement factor HpolymorphismPurpose: The Y402H polymorphism of the complement factor H (CFH) gene is associated with age-related macular degeneration (AMD) in many populations. The reported genotypephenotype correlations in the CFH Y402H polymorphism have not been pronounced and no studies on ...