Breast cancer is the most common cancer in women except skin cancer. The common metastatic sites include lymph node, lung, liver and bone.Charles Richardson
While it's true that metastatic breast cancer will eventually be fatal, most patients who find out they have it end up living with the disease for years. The average life expectancy is about three to five years from the time of diagnosis, says Newby. But, as research is advancing, so ar...
Osteosarcoma (OS) is the most common malignant bone tumor in children and adolescents. The survival rate of patients with metastatic disease remains very dismal. Nevertheless, metastasis is a complex process and a single-level analysis is not likely to i
early detection, the main goal of care could be the avoidance of cancer. By utilizing individualized risk calculation, the suitable timeframe for risk-reducing surgery is believed, and counselees may be supported in achieving preference-sensitive decisions. Cancer of the breast is a worldwide ...
Cancer Sci. 98, 874–881 (2007). CAS PubMed Google Scholar Witkiewicz, A. et al. Expression of indoleamine 2,3-dioxygenase in metastatic pancreatic ductal adenocarcinoma recruits regulatory T cells to avoid immune detection. J. Am. Coll. Surg. 206, 849–854; discussion 854–846 (2008)....
46 SIK1 is stimulated by a cancer suppressor LKB1, which leads to metastatic spread and invasiveness, as well as apoptosis resistance.47 Loss of SIK1 has been found in epithelial ovarian cancer and pancreatic cancer,48 and decreased SIK1 expression is correlated with poor outcome of breast ...
Progression of primary prostate cancer to castration-resistant prostate cancer (CRPC) is associated with numerous genetic and epigenetic alterations that are thought to promote survival at metastatic sites. In this study, we investigated gene copy number and CpG methylation status in CRPC to gain ins...
Construction and validation of a practical prognostic index for patients with metastatic breast cancer. To identify the readily available prognostic factors most helpful in predicting survival and to construct and validate a prognostic index for metastatic br... N Yamamoto,T Watanabe,N Katsumata,... ...
For these reasons, cancer cells overexpressing NUP93 might become rapidly proliferating and highly metastatic. This model can explain how SMAD proteins, which are escorted by Importin7/8, enhance TGF-β signaling (Xiao et al., 2003), as well as how signals mediated by GR and ERK, two ...
Cancer driver genes can undergo positive selection for various types of genetic alterations, including gain-of-function or loss-of-function mutations and copy number alterations (CNA). We investigated the landscape of different types of alterations affecting driver genes in 17,644 cancer exomes and ...