No person is born with a choice of genes. Alterations in DNA can result from a mutation in a single gene, chromosome abnormalities, or multi-factorial disorders. When genetic disorders do occur, they are often rare, and affect one person among thousands of individuals. ...
Mitochondrial inheritance Most genetic diseases are the direct result of a mutation in one gene. However, one of the most difficult problems ahead is to further elucidate how genes contribute to diseases that have a complex pattern of inheritance, such as in the cases of diabetes, asthma, cancer...
Scientists discover genetic secrets of seven common diseasesWILLIAM TINNING
20 Inflammatory bowel diseases 302 Jean-Pierre Hugot 21 Genetic anemias 316 W. G. Wood and D....
Age is a common risk factor in many diseases, but the molecular basis for this relationship is elusive. In this study we identified four disease clusters from 116 diseases in UK Biobank data, defined by their age-of-onset profiles, and found that diseases with the same onset profile are ge...
Identification of genetic susceptibility to common diseases: the case for regulation. There is, and will continue to be, pressure to disseminate and market population-wide availability of genetic susceptibility tests for common, complexly de... A Patricia,Baird - 《Perspectives in Biology & Medicine...
et al. An atlas of genetic correlations across human diseases and traits. Nat. Genet. 47, 1236–1241 (2015). CAS PubMed PubMed Central Google Scholar Okbay, A. et al. Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide...
While extensive research has been done since 1993, when the genetic cause of the disease was discovered [1], there is still no cure for this disease nor an effective treatment. Clinical and imaging biomarkers have been developed that measure the disease state and progression [2]. Nevertheless,...
et al. Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat. Genet. 44, 1294–1301 (2012). Article CAS Google Scholar Wakefield, J. A Bayesian measure of the probability of false discovery in genetic epidemiology studies. Am. J. Hum. Genet. 81, 208–227 (...
Preimplantation genetic testing (PGT) of in-vitro-fertilized embryos has been proposed as a method to reduce transmission of common disease; however, more comprehensive embryo genetic assessment, combining the effects of common variants and rare variants, remains unavailable. Here, we used a combinatio...