MAGMA: generalized gene-set analysis of GWAS data. PLoS Comput. Biol. 11, e1004219 (2015). PubMed PubMed Central Google Scholar Parikshak, N. N. et al. Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism. Cell 155, 1008–1021 (2013). CAS ...
The code base to reproduce the statistical and replication analyses presented in this paper is available from a public source code repository (https://gitlab.oit.duke.edu/dcibioinformatics/pubs/calgb-80405-pqtl). The genotype and phenotype (clinical and protein) data for the CALGB/SWOG 80405 dis...
Using stratified LD score regression (s-LDSC) with single-nucleus RNA-sequencing (snRNA-seq) data from adult human myocardial samples22, we observed enriched GWAS heritability near cardiomyocyte-specific genes for DCD, which may be explained by the inclusion of nonspecific intraventricular conduction d...
as both diseases were caused by coronaviruses.Footnote1However, most research on Singapore’s success against COVID-19 has tended to describe chronological, medical data (e.g., the death toll); the country’s in-house capacity resulting from its enhanced...
We set the time horizon at 2030 and 2050, because 2050 is an estimated peak for infrastructure renewal (Walta, 2015) and because 2030 can aid in connecting the present to that long time-period. We collected the quantitative data in multiple face-to-face seminars – instead of the common ...
Collecting and processing samples for the NEIGHBOR data set was supported by the NEI through American Recovery and Reinvestment Act (ARRA) grants 3R01EY015872-05S1 (J.L.W.) and 3R01EY019126-02S1 (M.A.H.). Genotype imputation and meta-analysis were supported by EY022305 (J.L.W.). ...
STATA SE12.0 (STATAcorp LP, College station, TX) was used to analyze and generate summary statistics of the data set. We compared variation frequency between cases and controls using either the Chi Square test (χ2) or Fisher's exact test and used the Mann–Whitney ...
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We used genome-wide gene expression data from disease hippocampus tissues to investigate the association between expression of M30 genes and epilepsy. Differential expression analysis was carried out using gene expression data from: (1) the human epileptic hippocampus (24 TLE patients/23 controls) assa...