编码的蛋白结构不同，基因表达模式不同。1、COL1A1编码的蛋白是类型I胶原蛋白，而COL3A1编码的蛋白是类型III胶原蛋白。2、COL1A1主要表达在成骨细胞、成软骨细胞和韧带等组织中，而COL3A1在许多组织中都有表达，包括皮肤、肌肉和内脏器官等。所以，col1a1和col3a1区别在于编码的蛋白结构不同，基因...
在整个肌肉发育过程中 COLlAl的表达量L匕COL3A1高。 讨论 胶原蛋白(collagen)是肌肉中结缔组织的主要成分,由于胶原(主要是IⅡ型胶原) 能够在肌纤维间和肌束周围广泛分布并形成微细的原纤维网,因此,其含量和交联度在 很大程度上影响肉品的感官及加工品质。肌肉组织中胶原蛋白含量的增加与肌肉本身的 发育过程是同步...
COL1a1COL3a1在发育性髋脱位患儿圆韧带的表达临床医学文1:COL1a1COL3a1在发育性髋脱位患儿圆韧带的表达临床医学 Abstract: [Objective]To investigate the expression of collagen type I and III at mRNA and protein level in the ligamentum teres of developmental dislocation of the hip(DDH) and the ...
COL1A1COL3A1胶原siRNA表达框目的 研究RNA干扰(RNAi)技术对人类皮肤成纤维细胞(HSF)COL1A1及COL3A1表达的影响.Ⅰ型胶原和Ⅲ型胶原是构成皮肤结缔组织的主要成 份,其异常是造成真皮结缔组织以及纤维增生性疾病病理变化的主要因素.RNAi技术可有效抑制特定基因的表达.方法 利用小干扰RNA(siRNA)表达框(SEC)快速筛选有效...
析,并经统计学处理。结果 COL1a1在DDH组mRNA及蛋白水平表达均较正常对照组降低(P<0.01);COL3a1在 DDH组mRNA水平表达较正常对照组降低(P<0.01),其蛋白水平表达与正常对照组无显著差异(P>0.05)。结 论DDH患儿关节囊中Ⅰ型胶原在mRNA及蛋白水平表达较正常同性同龄儿降低,可能是导致DDH患儿髋关节松 ...
KC0532P!;#;<<,(洗涤后用’#F鸡抗鼠A1K抗体$;$;<<<%杂交;D!化学发光法检测免疫反应条带$[GH F4_*!%5C0*D35!(QCEC2%&K%FN’为内参照蛋白& ;VT统计学处理 采用(F((;=V<进行统计学分析!计量资料均数的比较采用!检验!"! !结果 !V;’()形态学观察 ...
(COL1A1), COL3A1, andCOL1A2,wereenrichedin17radiation-associatedpathways.The three genes were upregulated in BCa tissues comparedwith controls and were also elevated by radiation. Theywere targeted by hsa-miR-29a/c, and the expression levelsof hsa-miR-29a/c were associated with a poor ...
(COL1A1 and COL1A2) or type-III collagen (COL3A1). Here, we performed linkage studies for these three genes in large Azerbaijanian family with EDS type I. Three polymorphisms in the COL3A1 gene, two in the COL1A1 gene, and one in the COL1A2 gene were tested using the polymerase...
应用:人III型胶原α1(COL3A1)酶联免疫elisa试剂盒可以在体外定量测定血浆、组织匀浆和其他生物液体中的人III型胶原α1(COL3A1)浓度. 检测方法:双抗夹心法 检测范围:31.25-2000pg/ml 灵敏度 lt; 18.75pg/ml 标准曲线: 回收率:将一定含量的人III型胶原α1(COL3A1)掺入下表列出的样本中,并通过将测量值与样...
The insulin like growth factor 1 (IGF1), matrix metallopeptidase 2 (MMP2), collagen type I alpha 1 chain (COL1A1), COL1A2, and COL3A1 gene had the interaction degrees of 30, 27, 22, 18, and 16, respectively. Figure 2 The PPI network and the important module of the radiation-...