笼统地讲,Ⅰ型Ehlers-Danlos综合征(EDS)是一种结缔组织疾病.主要表现为皮肤柔软,伸展过度及关节移动过度.根据临床,遗传及生化标准已确定了十几种类型的EDS,己识别出数种罕见型EDS的分子基础.然而,引起Ⅰ型EDS的基因缺陷仍未确定.但以前的观察资料提示该综合征可能由Ⅰ型胶原(COL1A1和COL1A2)或Ⅲ型胶原(COL3A1)...
Three polymorphisms in the COL3A1 gene, two in the COL1A1 gene, and one in the COL1A2 gene were tested using the polymerase chain reaction. The data obtained excluded linkage of any of the three genes to EDS type I in the family. This is a preview of subscription content, log in ...
In Kaplan Meier plotter, we found that high expression of COL1A1, COL1A2 and COL3A1 was associated with poorer survival while low expression of DCN was contributed to poorer survival in LAs who smoke. Thus, three up-regulated genes (COL1A1, COL1A2, COL3A1) and one down-regulated gene...
The expression of the COL1A1, COL3A1, and COL1A2 genes in the TCGA breast cancer tumor and normal control samples. The statistical differences were analyzed using the UALCAN online tool. Data was expressed as median and range (minimum to maximum).4...
Extracellular matrix containing mutated fibrillin-1 ( Fbn1 ) down regulates Col1a1 , Col1a2 , Col3a1 , Col5a1 , and Col5a2 mRNA levels in Tsk /+ and Tsk / ... It is known that the extracellular matrix (ECM) is able to signal to cells and thereby direct or modulate the ...
2006. Extracellular matrix contain- ing mutated fibrillin-1 (Fbn1) down regulates Col1a1, Col1a2, Col3a1, Col5a1, and Col5a2 mRNA levels in Tsk/þ and Tsk/Tsk embryonic fibroblasts. Amino Acids 30:445 - 451.Christner PJ, Ayitey S. Extracellular matrix containing mutated fibrillin-1 (...
Ⅰ型胶原α1(COL1a1)重组蛋白 Recombinant Collagen Type I Alpha 1 (COL1a1)COL-1A1; COL1-A1; COL1A-1; OI4; Collagen Alpha-1(I)chain [ PROPERTIES ]Source: Prokaryotic expressionHost: E.coliResidues: Lys1225~Val1453Tags: N-terminal His TagSubcellular Location: Secreted...
Exclusion of COL1A1, COL1A2, and COL3A1 genes as candidate genes for Ehlers-Danlos syndrome type I in one large family Ehlers-Danlos syndrome (EDS) type I is a generalized connective tissue disorder, the major manifestations of which are soft, velvety hyperextensible skin a... BP Sokolov,...
COKS COKT COL COL TRIBAL COL(P) COL11A1 COL18A1 COL1A1 COL1A2 COL2A1 COL3A1 COL4 COL5A1 COLA COLA1D COLAB COLAC COLACIBU COLAF COLAGE COLAN COLAND COLANTA CoLAP COLAPL COLAR COLAS COLATO COLB COLBA COLBC COLBERT CoLC ▼
[摘要]目的:研究人I型胶原基因COLIA1基因启动子区多态性与肝硬化性疾病的 相关性.方法:在l11例乙型肝炎病 毒感染后慢性肝硬化患者和95例正常对照中,用直接测序法对COL1A1基因启动 子区3个多态性位点进行基因分型.分析 单个位点的等位基因和基因型频率是否与肝硬化相关,并用单倍型推测软件计算 ...