Domain Binding and Function Coiled-coils (CC) function as oligomerization domains for a wide variety of proteins including structural proteins, motor proteins and transcription factors. The coiled-coil structure is conserved from viruses to plants and mammals and it has been predicted that approximately...
Nucleotide-binding, leucine-rich repeat re-ceptors are classified into coiled-coil (CC)-containing and Toll/interleukin-1 receptor (TIR)-containing NLRs. Recent advances sug-gest that NLR CC domains often function in signaling activation, especially for induction of cell death. In this review, ...
该基因有一个高度保守的区域，从真菌到人，序列很近，编码130个氨基酸残基（螺旋结构）。目前对其具体功能还没有研究。保守序列的比对在此 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam09745 人的mRNA全序列:http://www.ncbi.nlm.nih.gov/nuccore/NM_032141.2 ...
Plant nucleotide‐binding, leucine‐rich repeat receptors (NLRs) perceive pathogen avirulence effectors and activate defense responses. NLRs are classified into coiledヽoil (CC)ヽontaining and Toll/interleukinreceptor (TIR)ヽontaining NLRs. Recent advances suggest that NLR CC domains often function in ...
The coiled coil [1] is a widespread structural motif found both as the dominant structure in fibrous proteins and as an oligomerization domain in a variety of proteins [2]. Coiled coils consist of two or more α helices, supercoiled around one another, that associate in a parallel or an an...
Using SopB as a model coiled-coil domain type III effector, we have investigated the role of this motif in various aspects of effector function including chaperone binding, secretion and translocation, protein stability, localization and biological activity. Compared with wild-type SopB, SopB ...
The oligomerization of the coiled coil-domain of occludin is redox sensitive. The transmembrane tight junction protein occludin is sensitive to oxidative stress. Occludin oligomerizes; however, its function in the tight junction is u... JK Walter,C Rueckert,M Voss,... - 《Annals of the New ...
& Liu, Y. Coiled-coil domain-mediated FRQ-FRQ interaction is essential for its circadian clock function in Neurospora. EM... Top of pageIntroduction Results Discussion Materials and methods Acknowledgements References The frequency ( frq ) gene, the central component of the frq ... C Ping,Y ...
It was previously revealed that CCDC50 consists of one coiled-coil domain and two motifs that interact with ubiquitin domains that are known to function as a binding site for the ubiquitinated EGF receptor2,3. Based on this, we generated a series of deletion constructs of CCDC50-V2, such as...
a few coiled coils with hi 【gh degree linking connect the network as a center. We analyzed the molecular function of coiled coil protein.The result showed that the coiled coil prefers to exsit in the function of protein and DNA binding,motor proteins and structure moleculars that mediate bind...