An object that does not override init(coder:) can conform to NSSecureCoding without any changes (assuming that it is a subclass of another class that conforms). An object that does override init(coder:) must decode any enclosed objects using the decodeObjectOfClass:forKey: method. For exampl...
Download: Download full-size image Figure 1. Optogenetic tagging and manipulation of hippocampal CCK-positive interneurons (CCKIs) (A) Intersectional strategy using rAAV-C+F-ArchT-GFP targeting of CCKIs in dCA1. (B) Top: confocal images from a Dlx-FlpCCK-Cre mouse injected with rAAV-C+F...
For example, cold thermoreceptor neurons have regular spiking activity at resting temperatures of skin (33–34 °C) and bursting activity at lower temperatures. Period of bursting activity, burst duration, average interspike interval inside burst, and the number of spikes per burst increase with ...
A pan-cancer meta-cohort was created by combining all tumour cohorts except for Skin–Melanoma and lymphoid tumours (Supplementary Methods). Hotspot SNV analysis We selected the 50 most-frequent SNV hotspots. These were analysed to identify known driver events; mutational signature biases related to...
Selection for system-wide morphological, physiological, and metabolic adaptations has led to extreme athletic phenotypes among geographically diverse horse breeds. Here, we identify genes contributing to exercise adaptation in racehorses by applying geno
from the skin to all other organs, and from the function of the brain to that of a wiggling tail. A compelling example is that ofSRYgene, a transcriptional activator that acts exclusively on the fetal gonads to establish the synthesis of the gonadal sex hormones, which will pass the sex ...
Download: Download high-res image (757KB) Download: Download full-size image Fig. 2. Most dysregulated microRNAs in multiple sclerosis. Overview of the most replicated microRNAs (miRNAs) in multiple sclerosis (MS) in a minimum of 4 independent studies. MiRNAs are arranged from left to right ac...
Interactions among cis-regulatory elements (CREs) play a crucial role in gene regulation. Various approaches have been developed to map these interactions genome-wide, including those relying on interindividual epigenomic variation to identify groups of
The two principal cell types of importance for normal vessel wall physiology are smooth muscle cells and endothelial cells. Much progress has been made ove
Long non-coding RNAs (lncRNAs) perform distinct functions in various biological processes in mammals, including sex differentiation. However, the roles of lncRNAs in other vertebrates, especially in the Chinese soft-shell turtle (Pelodiscus sinensis), re