Synthetic coat protein complex I (COPI)-coated vesicles form spontaneously from large (≈ 300 nm in diameter), chemically defined liposomes incubated with coatomer, Arf1p, and guanosine 5′-[γ -thio]triphosphate. Coated vesicles are 40-70 nm in diameter, approximately the size of COPI ...
Coatprotein complexII (COPII) vesicle-mediated protein export from theendoplasmic reticulum(ER) can be controlled by linear, independent motifs embedded within the cargo.ERexport motifs directly interact with selective components of COPII vesicles and enhance cargo recruitment onto COPII vesicles. ...
TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry How RNA polymerase II subunits enter the nucleus is not well understood. Here, the authors show that Transport and Golgi organization protein 6, TANGO6, recruits RNA polymerase II subunit B2, RPB2, to the ER membra...
Coat protein complex-I (COPI) A specialized coat protein complex that is involved in the retrograde transport of cargo between the compartments of the Golgi and from the Golgi to the endoplasmic reticulum. Coat protein complex-II (COPII) A specialized coat protein complex that is involved in the...
Coat protein complex I (COPI) vesicles play a central role in the recycling of proteins in the early secretory pathway and transport of proteins within the Golgi stack. Vesicle formation is initiated by the exchange of GDP for GTP on ARF1 (ADP-ribosylation factor 1), which, in turn, ...
Luteolin decreases the yield of influenza A virus in vitro by interfering with the coat protein I complex expressionInfluenza A virusLuteolinAntiviral activityCOPIInfluenza is an acute transmissible respiratory infectious disease in humans and animals with high morbidity and mortality. It was reported ...
The coat protein complex I (COPI) has been implicated in the anterograde and retrograde transport of proteins and lipids between the endoplasmic reticulum and the Golgi. Here, we investigated the role of COPI in CFTR trafficking. Blocking COPI recruitment to membranes by expressing an inactive form...
J. et al. Assembly and solution structure of the core retromer protein complex. Traffic 12, 56–71 (2011). CAS PubMed Google Scholar Lucas, M. et al. Structural mechanism for cargo recognition by the retromer complex. Cell 167, 1623–1635.e14 (2016). CAS PubMed PubMed Central Google...
We report here that tomato (Solanum lycopersicum) COAT PROTEIN COMPLEX I (COPI) components play a critical role in redistributing Tomato yellow leaf curl virus C4 protein to chloroplasts via an interaction between the C4 and 尾 subunit of COPI. Coexpression of both proteins promotes the ...
Focuses on a study which assessed function of phospholipase D (PLD) and protein cargo in coat protein complex I (COPI) buds and vesicles' formation. Details on protein transport in cells; In-depth look at the formation process; Methodology used to conduct the study; Results of the study....