Effect of hypothermia on the coagulation cascade: Rohrer MJ, Natale AM Crit Care Med 20:1402–1405 Oct 1992doi:10.1016/S0196-0644(05)81963-8MDScott McCullochELSEVIERAnnals of Emergency Medicine
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20]. When the body is exposed to exogenous or endogenous damage, the coagulation cascade reaction is activated to stop bleeding and prevent the infection of pathogenic microorganisms and the possible inflammatory response [21,22]. Disruption of coagulation system function can cause severe damage...
Infections caused by drug-resistant “superbugs” pose an urgent public health threat due to the lack of effective drugs; however, certain mammalian proteins with intrinsic antibacterial activity might be underappreciated. Here, we reveal an antibacterial property against Gram-negative bacteria for factors...
Unpaired, two-tailed student’s t-test). h Schematic of initiated and inhibited coagulation cascade by traditional negatively charged surface and MS@D-HMP, respectively (created with BioRender.com). Source data are provided as a Source Data file. Full size image To evaluate the procoagulant ...
The clinical importance of our findings is underscored by the association between the observed disturbances in the coagulation cascade and the course of disease. Repeated testing during convalescence showed a return toward normal values. Acknowledgments We thank Wahid Rahman, Murad Hero and Nafiz Iqbal...
HAEMOSTASIS AND THROMBOSIS Regulation of coagulation Vessel wall injury Vasoconstriction, local blood pressure drop Activation of platelets Activation of plasmatic coagulation Activation of fibrinolysis Regulation by inhibitors and endothelial cells Formation of fibrin-platelet-thrombus Wound closure / cessation ...
The lipid peroxidation cascade generates a number of different intermediates depending on the target lipid species34. Malondialdehyde (MDA) is one of the major byproducts of lipid peroxidation and widely used as a biomarker of oxidative stress34. Therefore, to measure the overall lipid peroxidation ...
These events result in NET induction, which form a scaffold for the recruitment of components of the coagulation cascade. By interacting with the circulating neutrophils, the formed clot induces LDNs, which can further fuel coagulation in a positive feedback loop by undergoing NETosis and can ...
Among them, coagulation cascade proteins act in the early phase, and HGF-cMET signaling acts in the late phase of wound healing or adhesion development. By administering FF at different time points before and after surgery, we defined the hazardous time window for ovulation as one day before ...