该研究还确定了SCNSL的不同临床亚组(包括一组长期生存者),并验证了CNS-IPI的高危亚组。 参考文献 Incidence and Characterization of Secondary CNS Lymphoma in 1,972 Patients with DLBCL - A Danish Nationwide Cohort Study.Blood Adv . 2024 Nov 21:bloodadvances.2024014404. doi: 10.1182/bloodadvances.2024...
III-IV期霍奇金淋巴瘤国际预后评分（International Prognostic Score，IPS），有助于判断晚期HL的长期生存和指导治疗，包括7个不良预后因素，每增加一个不良预后因素，其5年无进展生存率降低8%。为方便记忆，将各项因素的英文名称首字母串联成MASAHWL （二） 非霍奇金淋巴瘤（NHL）国际预后指数 （IPI）非霍奇金淋巴瘤...
Central nervous system (CNS) relapse of diffuse large B-cell lymphoma (DLBCL) is associated with a poor prognosis, with a median overall survival of approximately five months [1]. The risk for CNS disease has been estimated to be about 5% overall [2], but it is significantly higher in ce...
Methods: We performed an IRB granted retrospective analysis of pts with de novo DHL based on assessing high-grade lymphoma FISH panels treated within the Advocate Health Care System. The pt's age, IPI score, CNS-IPI score, systemic treatment, CSF evaluation, CNS prophylaxis or treatment, CNS ...
The CNS international prognostic index (CNS‐IPI) is a clinical CNS relapse risk score that has not specifically been validated in elderly patients. The value of CNS prophylaxis in patients aged ≥70?years remains uncertain. Data on 690 consecutively R‐CHOP‐treated DLBCL patients aged ≥70?
Prophylaxis with high‐dose methotrexate significantly reduces CNS dissemination in patients with diffuse large B‐cell lymphoma (DLBCL) and high‐risk CNS‐IPI scoreIt is widely demonstrated that the PI3K-AKT-mTOR signalling is critical in normal myeloid and lymphoid development and function. Thus, ...
Site-specific risk factor for CNS recurrence among aaIPI score of 0-1 >1 extranodal site 5 3.6 Testicular lymphoma stage IIE or higher 2 1.4 Paranasal sinus and orbital lymphoma with destruction of bone 3 2.2 CNS IPI Low (0-1 factor) 4 2.9 Intermediate (2-3 factors) 72 52 High (...
The German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL) recently proposed a new prognostic model incorporating the 5 IPI factors (age > 60 y, LDH > N, stage 3 or 4, extranodal (EN) sites > 1) in addition to kidney/adrenal gland involvement to predict the risk of secondary CNS...
The CNS international prognostic index (CNS‐IPI) is a clinical CNS relapse risk score that has not specifically been validated in elderly patients. The value of CNS prophylaxis in patients aged ≥70years remains uncertain. Data on 690 consecutively R‐CHOP‐treated DLBCL patients aged ≥70years ...
CNS relapsediffuse large B-cell lymphomarituximabBritish Journal of HaematologyKansara R, Villa D, Gerrie AS, et al. Site of central nervous system (CNS) relapse in patients with diffuse large B-cell lymphoma (DLBCL) by the CNS-IPI risk model. Br J Haematol. 2016....