Hodgkin lymphoma (HL) represents a neoplasm primarily affecting adolescents and young adults, necessitating the development of precise diagnostic and monitoring tools. Specifically, classical Hodgkin lymphoma (cHL), comprising 90% of cases, necessitating
The International Prognostic Score (IPS) is the most commonly used risk stratification tool for patients with advanced Hodgkin lymphoma (HL). It incorporates seven clinical parameters independently associated with a poorer outcome: male sex, age, stage IV, hemoglobin level, white blood cell and ...
Hodgkin lymphoma (HL) is a B cell lymphoma characterized by few malignant cells and numerous immune effector cells in the tumour microenvironment. The incidence of HL is highest in adolescents and young adults, although HL can affect elderly individuals.
Classical Hodgkin lymphoma (CHL) is a unique type of B-cell lymphoma defined by the presence of characteristic neoplastic cells, termed Hodgkin- and Reed-Sternberg cells, in an exuberant inflammatory background. From:Diagnostic Histopathology,2015 ...
Herrera AF. SWOG S1826, a randomized study of nivolumab(N)-AVD versus brentuximab vedotin(BV)-AVD in advanced stage (AS) classic Hodgkin lymphoma (HL). Presented at: 2023 ASCO Annual Meeting in Chicago, IL at press conference on June 3, 2023. Accessed June 3...
Patients with advanced-stage Hodgkin lymphoma (HL) demonstrated excellent 2-year progression-free survival (PFS) after receiving positron emission tomography (PET)–adapted therapy on SWOG S0816. Patients received 2 cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD). Patients achievin...
Hodgkin lymphoma (HL) is one of the most curable malignancies in adults. However, survival rates for elderly patients with HL (often defined as ≥ 60 years of age) are inferior to those achieved by younger populations.
Classical Hodgkin lymphoma DDR1: Discoidin domain receptor 1 DFS: Progression free survival FCM: Flowcytoetry FFPETs: Formalin fixed, paraffin-embedded tissue HRS: Hodgkin/Reed-Sternberg IFTR: Involved Field radiotherapy IHC: Immunohistochemistry IPS: International prognostic score NCI: Nat...
Hospital, Washington, DC, USA; 2Seattle Cancer Care Alliance, Fred Hutchinson CRC, University of Washington, Seattle, WA, USA Abstract: The arrival of the CD30 directed antibody-drug conjugate, brentuximab vedotin (BV), has altered the approach to patients with classical Hodgkin lymphoma. Since...
Modern combination chemotherapy and radiotherapy have raised the long-term survival from Hodgkin lymphoma (HL) to more than 80% over the past decades.1 However, the longer follow-up has shown serious long-term adverse effects of the treatment, including heart and lung disease, and secondary malig...