III-IV期霍奇金淋巴瘤国际预后评分（International Prognostic Score，IPS），有助于判断晚期HL的长期生存和指导治疗，包括7个不良预后因素，每增加一个不良预后因素，其5年无进展生存率降低8%。为方便记忆，将各项因素的英文名称首字母串联成MASAHWL （二） 非霍奇金淋巴瘤（NHL）国际预后指数 （IPI）非霍奇金淋巴瘤...
The CNS International Prognostic Index (CNS-IPI) is a validated risk assessment model to help determine how high of a risk an individual patient may be for CNS relapse. It combines the traditional five IPI factors (age >60, elevated LDH, ECOG PS > 1, stage III/IV disease, and invol...
CNS relapse in patients with DLBCL according to CNS-IPI score and the initial therapydoi:10.1002/hon.2439_106E.HematologyVerrouHematologyA.HematologyGerofotisHematologyN.HematologyKarampatzakisHematologyA.HematologyPapadopoulouHematologyC.HematologyKeramidioti...
Prophylaxis with high‐dose methotrexate significantly reduces CNS dissemination in patients with diffuse large B‐cell lymphoma (DLBCL) and high‐risk CNS‐IPI scoreIt is widely demonstrated that the PI3K-AKT-mTOR signalling is critical in normal myeloid and lymphoid development and function. Thus, ...
The pt's age, IPI score, CNS-IPI score, systemic treatment, CSF evaluation, CNS prophylaxis or treatment, CNS event (yes/no), progression free survival and overall survival were recorded. Results: Thirty-one pts were evaluated. Seventeen were male. Median age was 72 years (range: 40 to ...
Site-specific risk factor for CNS recurrence among aaIPI score of 0-1 >1 extranodal site 5 3.6 Testicular lymphoma stage IIE or higher 2 1.4 Paranasal sinus and orbital lymphoma with destruction of bone 3 2.2 CNS IPI Low (0-1 factor) 4 2.9 Intermediate (2-3 factors) 72 52 High (...
CNS relapse in patients with DLBCL according to CNS‐IPI score and the initial therapydoi:info:doi/10.1002/hon.2439_106Verrou, E.Gerofotis, A.Karampatzakis, N.Papadopoulou, A.Keramidioti, C.Palaska, V.Papadaki, S.Katodrytou, E.
However, in multivariate analysis, only dual expresser status and CNS-IPI were associated with CNS relapse. Dual expresser MYC(+) BCL2(+) DLBCL defines a group at high risk of CNS relapse, independent of CNS-IPI score and cell of origin. Dual expresser status may help to identify a high...
CNS relapse in patients with DLBCL according to CNS‐IPI score and the initial therapys 16 th International Myeloma Workshop, March 1-4, 2017 | e213 and complete response was obtained in 22 patients (25%). Median progression free survival (PFS) was 36 months and median overall survival was...
The CNS international prognostic index (CNS‐IPI) is a clinical CNS relapse risk score that has not specifically been validated in elderly patients. The value of CNS prophylaxis in patients aged ≥70years remains uncertain. Data on 690 consecutively R‐CHOP‐treated DLBCL patients aged ≥70years ...