dizziness and depression of the CNS in occupational and accidental exposures. Until now there has been but little knowledge about the mechanisms of this anaesthetic action. We have studied the effects of aromatic, alicyclic and aliphatic solvents on synaptosome membranes isolated from rat whole ...
Topical beta-blocking agents have been associated with adverse central nervous system (CNS) effects, including depression, emotional lability, and sexual d... MG Lynch,JT Whitson,RH Brown,... - 《Arch Ophthalmol》 被引量: 61发表: 1988年 Investigating psychotropic properties of antiepileptic drugs...
2022 年 2 月 2 日,浙江大学脑科学与脑医学院崔一卉团队在Neuron杂志发表研究论文Hypothalamus-habenula potentiation encodes chronic stress experience and drives depression onset。 该研究以慢性束缚应激模拟慢性压力过程,在小鼠上诱导出持...
Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade. We tested a theoretical prediction that patterns of excitatory input activity that consistently fail to activate target neurons sufficiently to induce syna... SM Dudek,MF Bear - 《Pr...
The idea that there is a relationship between symptoms referable to the nervous system and endocrine effects has its origins in antiquity. The direct investigation of such relationships is, of course, of much more recent origin and the principal focus of
Cardiovascular effects of inhalation induction with isoflurane in infants. Anesth Analg 1983; 62: 111–4 Article Google Scholar Murray DJ, Forbes RB, Mahoney LT. Comparative hemodynamic depression of halothane versus isoflurane in neonates and infants: an echocardiographic study. Anesth Analg 1992; ...
Ethanol‐Induced CNS depression and divided attention Subject performed a divided attention task in which they detected occurrences of a target letter in a stimulus figure which was a large letter made up of a... SA Millar,L Duncan,B Tiplady - 《Human Psychopharmacology Clinical & Experimental》...
No significant effects were seen on the divided attention or continuous attention tasks, though continuous attention showed a trend towards impairment. These results suggest that the greater sensitivity showed by some multiple task combinations to low doses of drugs such as alcohol is not due to ...
In early phase clinical trials of new medicines, two of the major CNS pharmacodynamic questions that can be directly and widely addressed are first, whether the compounds have positive or negative effects on aspects of cognitive function and second, whether they will alter various mood states. The...
the signs and symptoms of PDImprovement in rigidity, tremor, depressionGood functional mobility can be maintained for many years Life expectancy is increased substantiallyHowever,disease progresses and may get worse Treatment with L-Dopa L-dopa therapy can’t block the progresse of PD "buffering" ...