Bare, Thomas MHeald, Anthony FUSUS4511568 1983年4月15日 1985年4月16日 Ici Americas Inc. CNS-Depressant pyrazolopyridinesUS4511568 * Apr 15, 1983 Apr 16, 1985 Ici Americas Inc. CNS-Depressant pyrazolopyridinesUS4511568 * 1983年4月15日 1985年4月16日 Ici Americas Inc. CNS-Depressant pyrazolo...
The present invention refers to a new class of pyrazolopyridines having analgetic, anxiolytic, antiinflammatory and CNS-depressant activity. It is described a process for producing the compounds as well as pharmaceutical compositions con... J Uinterusu 被引量: 0发表: 1984年 Synthesis and Antiprolife...
aconsider the potential for addictive sedative effects with cns depressant drugs 考虑在致瘾镇静作用的潜力与cns抑制剂药物 [translate] 英语翻译 日语翻译 韩语翻译 德语翻译 法语翻译 俄语翻译 阿拉伯语翻译 西班牙语翻译 葡萄牙语翻译 意大利语翻译 荷兰语翻译 瑞典语翻译 希腊语翻译 51La ...
On recognizing that he is being haunted, the subject enters immediately into "phase two," which, though varying in intensity from subject to subject, is always disagreeable: often sedation (0.6 mg atropine subcut.) will be necessary, even though Oneirine is classified as a CNS depressant. Gra...
The findings with atomoxetine and bupropion raise the question as to whether these compounds exert their clinical effects through mechanisms other than monoamine reup- take inhibition. Alternatively, a low blockade of the NET and the DAT, respectively, might be sufficient for anti- depressant response...
What are the adverse effects of opioids (CNS depressants) Respiratory Depression - within 7-10 mins IV - can persist up to 4-5 hrs (NALOXONE REDOSING NEEDED) - worsened if on 1+ depressant Decreased BP/ P Sedation/ Drowsiness Muscle Weakness Dizziness/ Safety issues Constipation/ Urinar...
-side effects include headache and nauseaSodium Oxybate (Xyrem)-GABA B agonist-strong CNS depressant-naturally occurring in our body and in foods-GHB alone is schedule 1-Xyrem is schedule 3-for cataplexy-not used in the morning, pts with cataplexy take 2 doses at night before bedtime about...
. In the absence of a deeper understanding of disease pathology and mechanisms of side effects, CNS drug discovery would remain dominated by the redesign of drugs for familiar targets and reduced approval rates for ‘me too’ drugs. The ability to evaluate changes in the expression of the ...
since the mean maximum plasma concentration and area under the plasma concentration-time curve are increased in these patient groups. Dosage adjustment of zolpidem may also be required when coadministered with CNS-depressant drugs as these agents may enhance the CNS effects of any hypnosedative drug...
A traditional mood stabilizer, lithium, functions as a mild GSK-3β inhibitor and an anti-depressant, fluoxetine, could induce GDF-15 from astrocytes [69, 218]. Both activate PI3K/Akt signaling pathway, and then inhibit RhoA-mediated cell contraction by eNOS activation. Epilepsy As 10–25% ...