Noun1.depressant- a drug that reduces excitability and calms a person downer,sedative,sedative drug chloral hydrate- a colorless crystalline drug used as a sedative; irritates the stomach and can be addictive drug of abuse,street drug- a drug that is taken for nonmedicinal reasons (usually for...
Overdose with the succinimides is rare. The effects seen include lethargy, coma and respiratory depression. The treatment of an overdose of the succinimide derivatives is primarily supportive. Symptoms of phenobarbital (phenobarbitone) overdose are generally exacerbations of the CNS depressant effects seen...
作者: MA Schuckit 摘要: The central nervous system (CNS) depressant drugs include a variety of medications, such as hypnotics, most antianxiety drugs (also called minor tranquilizers),and alcohol.1As discussed in greater... DOI: 10.1007/978-1-4757-0767-0_2 收藏...
The symptoms can be associated with high concentrations of Opioids and their metabolites in CSF, but can also be caused by pharmacological interactions between Opioids and other drugs commonly used in clinical practice. Moreover, they may be related to the accumulation of active metabolites in patien...
Anti-depressant agents useful in the dosage forms include by way of example the tricyclic antidepressants LIMBITROL® (amitriptyline; Hoffmann-LaRoche, Nutley, N.J.), TOFRANIL® (imipramine; Tyco Healthcare, Mansfiled, Mass.), ANAFRANIL™ (clomipramine; Tyco Healthcare, Mansfield, Mass.),...
-depressant efficacy to citalopram (single study), fluoxetine, paroxetine and sertra-line (single study). Overall, the proportion of patients classified as HAM-D responders at endpoint in these trials was 50—73% for mirtazapine, 45—71% forfluoxetine, 50—56% for paroxetine and 52% for ...
and to exert a direct neuronal membrane depressant effect, via modulation of sodium and potassium conductance. Moreover, it may also modulate noradrenergic and serotonergic neurotransmission. Valproic acid has also been reported to alter circadian rhythms in animals, possibly via effects on GABAergic fu...