These similar cases have raised the possibility of an association with Nilotinib and CNS demyelination. Although likely to be a rare phenomenon, clinicians should have a low threshold for considering demyelination in patients presenting with neurological symptoms....
[4] Hardy T A, Chataway J. Tumefactive demyelination: an approach to diagnosis and management[J]. Journal of Neurology Neurosurgery & Psychiatry, 2013, 84(9):1047-1053. [5] Todd A Hardy, David H Miller. Baló's concentric sclerosis[J...
In patients discontinuing TNFai (18/21, 86%) at INE onset, 56% (10/18) had further evidence of CNS demyelination. Six patients (6/21, 29%) started an MS disease modifying therapy (DMT) at INE of whom 50% (3/6) had subsequent disease activity. Continuing or restarting TNFai was ...
2022年2月24日陕西师范大学张媛团队在Elife上发表研究论文Atmospheric particulate matter aggravates CNS demyelination through involvement of TLR-4/NF-kB signaling and microglial activation[2],通过互补的病理和生理脱髓鞘/髓鞘形成模型,发现并证实PM2.5...
These cells respond to demyelination by activation, proliferation, migration and finally differentiation into remyelinating oligodendrocytes; it is the last of these processes that is most likely to fail in MS and leave areas of demyelination containing oligodendrocyte-lineage cells that are unable to ...
After central nervous system (CNS) demyelination—such as occurs during multiple sclerosis—there is often spontaneous regeneration of myelin sheaths, mainly by oligodendrocytes but also by Schwann cells. The origins of the remyelinating cells have not previously been established. We have used Cre-lox...
Remyelination is neuroprotective, limiting the axonal degeneration that follows demyelination. Restoring remyelination is therefore an important therapeutic goal so as to prevent neurodegeneration and progressive disability in multiple sclerosis and other myelin diseases. Insights into the mechanism governing re...
Recently we have showed that mycoplasma can trigger the production of tumor necrosis factor (TNF)alpha and eicosanoids in rat astrocytes. In...doi:10.1016/0165-5728(95)98888-IT. BrennerM. GalperinR. GallilyC. SicsicL. SteinmanJournal of Neuroimmunology...
To determine the potential activity of MSP in CNS demyelination, we examined its expression in multiple sclerosis lesions and in two animal models of multiple sclerosis: Theiler's murine encephalomyelitis virus (TMEV) and myelin oligodendrocyte glycoprotein (MOG)-induced experimental allergic ...
Several lines of evidence indicate that the immune response plays a key role in these diseases, although the actual pathogenic pathways leading to demyelination are frequently unclear. The prototypical inflammatory demyelinating disease of the CNS is MS, which is traditionally considered to be due to...