CNS demyelination in autoimmune diseases. Clin Neurol Neurosurg. 2006; 108(3): 318-26.Brinar VV, Petelin Z, Brinar M, et al. CNS demyelination in autoimmune diseases. Clin Neurol Neurosurg. 2006;108:318–26.Brinar VV, Petelin Z, Brinar M, Djakovic V, Zadro I, Vranjes D (2006) ...
Curr Neurol Neurosci Rep (2017) 17: 36 DOI 10.1007/s11910-017-0742-1 DEMYELINATING DISORDERS (D N BOURDETTE & M CAMERON, SECTION EDITORS) CNS Demyelination with TNF-α Blockers Elissavet Kemanetzoglou1,2 & Elisabeth Andreadou2 Published online: 21 March 2017 # The Author(s) 2017. This ...
The term inflammatory demyelination encompasses a broad spectrum of CNS disorders that can be differentiated according to their severity, clinical course, and lesion distribution, as well as their imaging, laboratory, and pathological findings. The spectrum includes monophasic, multiphasic, and progressive...
Figure 7. hiPSC-EC transplantation attenuates myelin damage and enhancesremyelination after LPC induced demyelination. 既往机制研究指出,OPCs向成熟髓鞘少突胶质细胞的发展过程,涉及多种内在信号通路的复杂相互作用,包括MAP激酶通路、mTOR通路和Wnt信号通路,同时也会受到一系列外部因素的调控。脑微血管可通过其内部内...
[4] Hardy T A, Chataway J. Tumefactive demyelination: an approach to diagnosis and management[J]. Journal of Neurology Neurosurgery & Psychiatry, 2013, 84(9):1047-1053. [5] Todd A Hardy, David H Miller. Baló's concentric sclerosis[J...
H and E: inflammation luxol fast blue: demyelination axonal injury components of MS pathophysiology CNS Inflammation:1. Peripheral immune cell infiltration2, CNS immune cell activation3. Blood-brain barrier disruption4. Intrathecal synthesis of IgG: immune-mediated CNS inflammation describe the peripheral...
Figure 7. hiPSC-EC transplantation attenuates myelin damage and enhances remyelination after LPC induced demyelination. 既往机制研究指出,OPCs向成熟髓鞘少突胶质细胞的发展过程,涉及多种内在信号通路的复杂相互作用,包括MAP激酶通路、mTOR通路和Wnt信号通路,同时也会受到一系列外部因素的调控。脑微血管可通过其内部内...
13 Demyelinating Diseases of the CNS (Brain and Spine) 195 13.6 Acute Disseminated with acute CNS demyelination [23]. Unlike the lesions in Encephalomyelitis (ADEM) MS, ADEM lesions are often large, patchy, and poorly mar- ginated on MRI, especially when there are MOG antibodies ...
Since the declaration of COVID-19 pandemic, several case reports of demyelination of both peripheral and central nervous systems have been published. The a
However, it is not known if androgens are required for spontaneous remyelination in females or how androgens may act in the female demyelinated CNS. Here, we addressed these questions by using pharmacological and genetic approaches in immune and non-immune models of CNS demyelination. We show ...