induced by immunization with myelin antigens, stimulating a myelin-specific Th1/Th17 response that results in CNS inflammatory lesions, demyelination, axonal loss, and neurological dysfunction [9,10]. The etiology of MS is complex, with both genetic and environmental underpinnings. Environmental risk f...
Our data show that co-administration of E2 and IL-10+ B cells ameliorates EAE disease severity and limits CNS infiltrating leukocytes in B cell deficient mice. Additionally, treatment with E2 and Bregs reduces demyelination and dramatically decreases the proportion of CD11b+CD45hi activated ...
Allen IV, McQuaid S, McMahon J, Kirk J, McConnell R (1996) The significance of measles virus antigen and genome distribution in the CNS in SSPE for mechanisms of viral spread and demyelination. J Neuropathol Exp Neurol 55:471–480 PubMed CAS Google Scholar McQuaid S, Cosby SL (2002) An...
Central neuropathic pain is caused by a disease or lesion of the brain or spinal cord. It is difficult to predict which patients will develop central pain syndromes after a central nervous system injury, but depending on the etiology, lifetime prevalence may be greater than 50%. The resulting ...