Our data show that co-administration of E2 and IL-10+ B cells ameliorates EAE disease severity and limits CNS infiltrating leukocytes in B cell deficient mice. Additionally, treatment with E2 and Bregs reduces demyelination and dramatically decreases the proportion of CD11b+CD45hi activated ...
induced by immunization with myelin antigens, stimulating a myelin-specific Th1/Th17 response that results in CNS inflammatory lesions, demyelination, axonal loss, and neurological dysfunction [9,10]. The etiology of MS is complex, with both genetic and environmental underpinnings. Environmental risk f...
Interestingly, these mice also display less demyelination than wild-type EAE controls [134]. In a prior study, we imaged and evaluated the ability of endogenous DCs to transmigrate across the BBB during EAE and assessed both mechanism and extent of chemotaxis and diapedesis in the presence of ...
Central neuropathic pain is caused by a disease or lesion of the brain or spinal cord. It is difficult to predict which patients will develop central pain syndromes after a central nervous system injury, but depending on the etiology, lifetime prevalence may be greater than 50%. The resulting ...
If the balance tips towards one side, it can cause neoplastic proliferation, while on the other spectrum can lead to extensive demyelination. Female MS patients were more likely to have both neurological conditions. The average age was 62.2 years, speculating that some of these patients still had...