By making direct comparisons to the analogous Fe II complex, we found that cyanide electronically behaves as a strong-field ligand for both metals because the orbital interaction is energetically more favorable in the low-spin configuration than in the corresponding high-spin configuration. The ...
Fluorescence of 2,3-diaminonaphthalene is weak. Reaction with nitrite yields highly fluorescent 1H-naphthotriazole (Abs = 365 nm, Em = 415 nm in H2O (pH 12)). DAF-FM fluorescence is very weak. Reaction with nitrite or nitric ...
Weak or transient protein–protein interactions can be strengthened by covalently crosslinking the interacting proteins prior to pull-down. While this strategy is more advanced than performing the pull-down assay without crosslinking, freezing protein intera...
Two weak bands were observed for the cyanide NCBeCN, and three absorptions were found for the mixed ligand CNBeCN molecule, which would be difficult to synthesize and put into a bottle. Mg reacts with (CN)2 to form the CNMgNC counterpart at 2085.8 cm-1 on annealing to 25 K. ...
The absorption bands observed in the visible region were assigned to the d-d transitions of M(II) in the octahedral weak field, while those observed in the near u.v. region were assigned to the ligand field bands of Rh(III) in the octahedral strong field....
In cynomolgus monkeys, the LALA-mutated ADC had a half-life of 82 hours at a dose of 0.2 mpk, and target-mediated drug disposition appeared weak or negligible. Our preclinical studies have shown that CLEC12A targeting ADC can be used as a therapeutics for treating AML. Abstract 6297: ...
Indeed, in both strong RPH2···IF and weak RPH2···FI complexes, the structural features hint at striking resemblances to familiar H-bonding phenomena, including deep sub-vdW penetration (with concomitant covalent bond RIF elongation) and pronounced “linearization” tendency (albeit along ...
FITM is a negative allosteric modulator of mGlu1 receptor with a Ki of 2.5 nM. FITM fits tightly into the long and narrow pocket. Most of the ligand-receptor interactions are hydrophobic with the exception of the contacts of the pyrimidine-amine group with the T815 7.38 side chain. The ...
of multi-electron reduction transitions in a solution of2at moderate potential values. The ambidentate CN−ligand is the secondary functional group, which has potential for the synthesis of coordination polymers based on the new cluster complexes. In addition, both new compounds show a weak red...
Most affinity purification procedures involving protein:ligand interactions use binding buffers at physiologic pH and ionic strength, such as phosphate buffered saline (PBS). This is especially true when antibody:antigen or native pro...