Also farnesol, proved to be as good a ligand as (E)-β-farnesene, whereas exo-brevicomin did not show any affinity. Dissociation constants were evaluated using the procedure adopted when dealing with solutions of a pure protein; as this is not the case, the values have to be taken as ...
The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. Cell 105, 391–402 (2001). Article CAS Google Scholar Ishiyama, N. et al. Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of...
The ligand is then bound as a Mg.acetaldimine(ethanimine).porphin complex. This mechanism constitutes another mechanism for the formation of reactive, and unstable, imines that could facilitate the formation of aziridine-2ones, which have been predicated as important in amino-acid synthesis (Aylward...
The nature of VSIG1-dependent genes prominently expressed by the SP suggested that VSIG1 represses calcium binding (PRKCG and SYT17), microtubule/dendrite localization (MAP2 and TUB1A1), signaling (GLI1, TAZ, PDGFA ligand, and the WNT antagonist NKD1), migration/protein trafficking (TUB1...
Hermida N, Balligand JL. Low-density lipoprotein-cholesterol-induced endothelial dysfunction and oxidative stress: the role of statins. Antioxid Redox Signal. 2014;20(8):1216–37. Article CAS PubMed Google Scholar Seo E, Kang H, Choi H, Choi W, Jun HS. Reactive oxygen species-induced chan...
In addition to IL-33, IL-25 is also a strong inducer of ILC2s (Huang et al., 2015). ILC2s induced by IL-25 are termed “inflammatory” ILC2s (iILC2s) that are generated under inflammation or infections (Huang and Paul, 2016, Saunders et al., 2014). When WT and IRF7−/− ...
Among other soluble factors it secretes chemokines, in particular stromal-derived factor 1 (SDF-1) [104], the natural ligand for CXCR4 that in vitro selectively suppresses X4 HIV-1 but not R5 HIV-1 infection [62]. Even with intact epithelia, HIV-1 may be transmitted through the epithelial...
Is cyanide an Ambidentate ligand? Cyanide, as anambidentate ligand, plays a pivotal role in providing a simple diatomic building- block motif, for controlled metal aggregation, M-CN-M'. Specifically, the inherent hard-soft nature of the cyanide ligand, i. ...
(AgNPs) because of their remarkable results with multidrug-resistant bacteria. This study was conducted on the preparation of AgNPs, using the teucrium apollinis extract as a reducing agent and a capping ligand. The AgNP produced was stable in room condition up to 10 weeks. The AgNP was ...
2-oxokolavenol forms two hydrogen bonds with M265 and Y369 of human FXR to compatibly fit into the ligand binding pocket of FXR, which potently leads to the recruitment of multiple co-regulators and selectively induces the transcriptional activity of FXR. Our findings thus not only reveal the...