6. In addition to energy production, mitochondria regulate many other critical cellular functions such as reactive oxygen species (ROS) generation, calcium flux, macromolecule biogenesis (i.e., protein and nucleic
Introduction : On top of their established essential bioenergetic role, mitochondria are responsible for critical cellular processes that cancers may coopt to gain heightened fitness. Multiple myeloma (MM) cells show abundant and intensely turned-over mitochondria, with heightened mitochondrial biogenesis ...
The Mouse Heart Mitochondria N Terminome Provides Insights into ClpXP-Mediated Proteolysis Molecular & Cellular Proteomics, Volume 19, Issue 8, 2020, pp. 1330-1345 Eduard Hofsetz,…, Pitter F. Huesgen View PDFShow 3 more articles Article Metrics Citations Citation Indexes215 Captures Readers193...
Caseinolytic protease proteolytic subunit (ClpP) and caseinolytic protease X (ClpX) are mitochondrial matrix peptidases that activate mitochondrial unfolded protein response to maintain protein homeostasis in the mitochondria. However, the role of ClpP and ClpX in spermatogenesis remains largely unknown. ...
Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength. mouseWB Nat Commun Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells. See more citations...
Mitochondria are best known as the powerhouse of eukaryotic cells for ATP production through oxidative phosphorylation (OXPHOS)1. The electron transport chain (ETC), consisting of four multiprotein complexes (CI-IV), is the primary executor of OXPHOS. The ETC receives electrons from the tricarboxylic...
Most cells had some DVE-1 staining, but the strongest signal was observed in the mitochondria-rich intestinal precursor cells. The validity of the anti-DVE-1 staining is supported by the diminished signal in embryos born to dve-1(RNAi) mothers and by its concordance with the fluorescent ...
response (mtUPR) to maintain protein homeostasis.Clpp−/−female mice generate a lower number of mature oocytes and two‐cell embryos, and no blastocysts.Clpp−/−oocytes have smaller mitochondria, with lower aspect ratio (length/width), and decreased expression of genes that promote fusion...
Therefore, mitochondria homeostasis is tightly regulated. Cancer cells rely heavily on mitochondria to meet their high energy demands and generate macromolecules used as building blocks to fuel rapid cancer cell proliferation1,3,4. Additionally, mitochondria serve as a central signaling hub that ...
Introduction Mitochondria are intracellular organelles that produce the majority of energy in cells by synthesizing ATP via oxidative phosphorylation. Beyond cellular bioenergetics, mitochondria have many other functions including reg- ulation of redox balance, metabolite biosynthesis, reg- ulation of calcium...