We present an 'endogenous' framework for the collective impact that uses the Community Life Project Platform (CLPP) for specific design deployments, including a design process and design module. The research shows that Community Design 3.0 combines both short-term design interventions and long-term ...
This method leads providers, executives, and clinical leaders through the concepts and skills required for the successful design, implementation, and adoption of Expanse. The program incorporates a combination of demonstrations, presentations, collaborative exercises and insightful discussions with our CLPP ...
In this paper, a new user-friendly platform for robust observer design is presented. The aim of this software is to render the process of observer design as simple as possible for process practitioners and researchers involved in control or supervision tasks. The platform is dedicated to laborator...
a Design of the Cre-LoxP cKO system in the ClpP/ClpX allele, such that exon 3–5 was flanked by two LoxP regions in the ClpP allele, and exon 3 was flanked by two LoxP regions in the ClpX allele. When combined with Cre protein, exon 3–5 is deleted to complete ClpP gene knock-ou...
The subcellular pathways central to the survival of the bacteria during the infection are attractive candidates for new drug design. In such an effort, the acyldepsipeptides (ADEPs), a new class of antibacterial compound and its derivative were found to target the caseinolytic protease (ClpP ...
Mitochondrial ClpP is a serine protease located in the mitochondrial matrix. This protease participates in mitochondrial protein quality control by degrading misfolded or damaged proteins, thus maintaining normal metabolic function. Mitochondrial ClpP is
MSCCL++ redefines inter-GPU communication interfaces, thereby delivering a highly efficient and customizable communication stack for distributed GPU applications. Its design is specifically tailored to accommodate diverse performance optimization scenarios often encountered in state-of-the-art AI applications. ...
These structural features can be used to design different ClpP activators with high species-specificity. Interestingly, HsClpP activators exhibit antitumor effects but trigger distinct signaling pathways in different cancer cells. Both ONC201 and ZG111 cause significant cell apoptosis. ONC201 induces an ...
In view of these considerations, the aim of this study was to clone and express ClpP using Escherichia coli as a host, optimize protein production using experimental design and study the plasmid stability of the system. As such, central composite design was used for two variables: concentration ...
A GPU-driven communication stack for scalable AI applications. See Quick Start to quickly get started. Overview MSCCL++ redefines inter-GPU communication interfaces, thereby delivering a highly efficient and customizable communication stack for distributed GPU applications. Its design is specifically tailore...