Recent studies have shown that cancer stem cells (CSCs) preferentially use mitochondrial oxidative metabolism for energy production. Here, we report that ClpP agonists inhibit breast CSCs by unique mechanisms targeting pathways vital to maintain CSC function. Methods: ONC201 and other ClpP agonists (...
Additionally, mito- chondria serve as a central signaling hub that integrates extracellular and intracellular signaling pathways and nutrient status controlling epigenetics, stemness, cell cycle regulation, and apoptosis and are thus involved in all phases of cancer initiation, progression, and metastasis5...
Additionally, mitochondria serve as a central signaling hub that integrates extracellular and intracellular signaling pathways and nutrient status controlling epigenetics, stemness, cell cycle regulation, and apoptosis and are thus involved in all phases of cancer initiation, progression, and metastasis5,6...
Considering several recent reports showing that cancer stem and chemo-resistant cells rely highly on oxidative phosphorylation (Farge et al., 2017, Kuntz et al., 2017, Lagadinou et al., 2013, Marin-Valencia et al., 2012, Viale et al., 2014), we speculate that this therapeutic approach ...
AML cells and stem cells, as well as subsets of other malignancies such as chronic myeloid leukemia (CML), pancreatic and breast cancer49,59,60,61,62,63,64have unique mitochondrial characteristics with increased reliance on oxidative phosphorylation. The increased reliance on oxidative phosphorylation...
We next differentiated induced pluripotent stem (iPS) cells from PD patient carrying αSyn A53T and its isogenic corrected control into neuronal cells. The neuronal cells derived from αSyn A53T PD patient iPS cells exhibited an accumulation of αSyn serine 129 phosphorylation (αSyn-pS129), a...
Mitochondria‐specific antioxidant MitoTEMPO alleviates senescence of bone marrow mesenchymal stem cells in ovariectomized rats Senescence in bone marrow mesenchymal stem cells (BMSCs), triggered by excessive oxidative stress, plays a crucial role in the onset of postmenopausal oste... J Li,D Zhang,Y...
Cancer cells depend on aberrant antioxidant mechanisms to survive increased oxidative stress, which is particularly critical for cancer stem cell maintenance and its therapy resistance phenotype. Mitochondria is the primary site of oxygen consumption and reactive oxygen species (ROS) production, thus is ...
(AML) in vivo recently7,8. Based on the scaffold of ONC201, ClpP activators such as 16z, TR-107 and IMP075 with enhanced enzymatic and anti-proliferative activity in cancer cells were developed. These derivatives also showed anticancer efficacy in vivo9,10,18. We also identified pyrimidone ...