Routes ofadministration Oral Legal status Legal status Prescription only, special restrictions imposed in many countries Pharmacokinetic data Bioavailability 60 to 70% Metabolism Hepatic, by several CYP isozymes Biological half-life 6 to 26 hours (mean value 14.2 hours in steady state conditions) Excreti...
Just prior to administration of orally disintegrating tablet, peel foil blister backing completely off the blister and gently remove tablet; do not push tablet through the foil. Immediately place on the tongue to dissolve and swallow with or without liquid; tablet also can be chewed....
routes of administration, pharmacokinetics, side effects, dosages, and challenges associated with intrathecal clozapine administration. The hypothesis suggests potential advantages, such as reduced systemic side effects due to the reduced dose and lower plasma levels of intrathecal clozapine. Intrathecal ...
The mean volume of distribution at steady-state and the terminal half-life was 1.6 l/kg and 10.3 h, respectively. A large fraction of the dose is most probably metabolized by some extrahepatic presystemic routes. The large inter-individual variability in the bioavailability and clearance is ...
The pharmacokinetic, safety, and pharmacodynamic effects of LNCsClo were then evaluated in a rat model through intranasal (IN) administration and compared with those of oral and intravenous (IV) Clo solutions. Results: LNCsClo were prepared using a phase inversion technique, resulting in a ...