The woman, who had a history of bipolar disorder, received clozapine at a dosage increased from 50mg to 250mg [ route and frequency of administration not stated ] over a 7-day period. After 10聽days of clozapine treatment, she suddenly developed a fast rising fever, neck stiffness, and ...
Please develop an appropriate dissolution method based on your laboratory animals and route of administration. 1 Enter information below: Dosage mg/kg Average weight of animals g Dosing volume per animal μL Number of animals 2 Enter the in vivo formulation: % DMSO % %Tween 80 %ddH2O ...
Just prior to administration of orally disintegrating tablet, peel foil blister backing completely off the blister and gently remove tablet; do not push tablet through the foil. Immediately place on the tongue to dissolve and swallow with or without liquid; tablet also can be chewed....
(Fig. 1). This route of administration is theorized to offer potential advantages compared to current methods of clozapine delivery [12], [13]. By directly injecting clozapine into the CSF, intrathecal administration may overcome some of the limitations associated with oral or other forms of ...
included demographics (sex, age, ethnicity); principal diagnosis (Diagnostic and Statistical Manual of Mental Disorders, 4th edition); comorbid conditions; duration of mental illness; psychiatric admissions; and treatment information (psychotropic medications, with dose and route of administration). If...
Figure 1 the synthesis route of clozapine Precautions 1. Induction of the decrease of neutropenia or its development into agranulocytosis is the most serious side effects of this product. So do not take drugs which causes leukopenia simultaneously while taking clozapine, especially avoid taking the ...
A 60-year-old man with schizophrenia started receiving clozapine and subsequently developed seizures [ dosage, route and duration of treatment to reaction onset not stated ]. Clozapine was replaced with risperidone. MRI findings included asymmetric and enlarged third and fourth ventricles [ outcome not...
Therapeutic drug management would provide the clinician with insight on patient variation in drug administration. With therapeutic drug management, drug dosages could be individualized to the patient, and the chances of effectively treating the disorder without the unwanted side effects would be much ...
weekly haematological surveillance is essential during the initial 18 weeks of clozapine administration; thereafter monthly monitoring is considered satisfactory. Clozapine is contraindicated in conjunction with drugs with the potential to depress bone marrow function/induce agranulocytosis, as well as in pat...
route is often painful, with low patient compliance and requiring specialised personnel. Moreover, CZP has a very low aqueous solubility. This study proposes the intranasal route as an alternative route of administration for CZP, through its encapsulation in polymeric nan...