Clozapine: Once-Daily or Divided Dosing?Miller, BrianPsychiatric Times
Dosing information Usual Adult Dose for Schizophrenia: Initial dose: 12.5 mg orally once or twice a day Titration and Maintenance dose: May increase total daily dose in increments of 25 mg to 50 mg per day to a target dose of 300 mg to 450 mg per day (administered in divided doses) by...
The starting dose of Versacloz is 12.5 mg once daily or twice daily. The total daily dose can be increased in increments of 25 mg to 50 mg per day, if well-tolerated, to achieve a target dose of 300 mg to 450 mg per day (administered in divided doses) by the end of 2 weeks. ...
Pediatric Dosing Treatment-resistant schizophrenia and schizophrenia-associated suicide prevention - 125 to 475 mg orally daily in 2 or 3 divided doses. Start 12.5 mg daily or twice daily, and increase by 12.5 to 25 mg daily every 3 to 5 days as tolerated. The maximum dose is 700 mg daily...
Dosing Information The starting dose is 12.5 mg once daily or twice daily. The total daily dose can be increased in increments of 25 mg to 50 mg per day, if well-tolerated, to achieve a target dose of 300 mg to 450 mg per day (administered in divided doses) by the end of 2 weeks...
Resume treatment once ANC ≥1000/mm3 Daily until ANC ≥1000/mm3 3 times weekly until ANC ≥1500/mm3 When ANC ≥1500/mm3, monitor weekly for 4 weeks, then return to the patient's last “normal range” ANC monitoring interval (if clinically appropriate) Severe neutropenia (ANC <500/mm3) ...
12.5 mg orally once daily or every 12 hours initially; increase in increments of 25-50 mg/day, if well tolerated, to achieve target dosage of 300-450 mg/day (administered in divided doses) by end of 2 weeks Subsequently, may increase dose once or twice weekly in increments of up to ...
In patients who have had even a brief interval off clozapine, i.e., 2 or more days since the last dose, treatment should be started with 12.5 mg once or twice daily. Since collapse, respiratory arrest and cardiac arrest during initial treatment has occurred in patients who were being ...
Once the patient is stabilized and the maintenance dose has been determined, the greater part or all of the daily dose may be given at bedtime.[30] This will ameliorate daytime sedation and orthostatic problems; most people benefit from the sedation to get to sleep anyway. Furthermore, ...
Dosing Information The starting dose is 12.5 mg once daily or twice daily. The total daily dose can be increased in increments of 25 mg to 50 mg per day, if well-tolerated, to achieve a target dose of 300 mg to 450 mg per day (administered in divided doses) by the end of 2 weeks...