This consensus statement reflects the current practice at five major public psychiatric hospitals in Victoria, Australia, for the monitoring and management of clozapine-related adverse events, and has been implemented at these sites because of emerging safety concerns associating clozapine with ...
Despite the implementation of cardiac monitoring guidelines, clozapine-induced myocarditis continues to cause deaths in Australia, and the risk is a barrie... KJ Ronaldson,PB Fitzgerald,AJ Taylor,... - 《Schizophrenia Research》 被引量: 70发表: 2012年 Clozapine-induced hypersensitivity myocarditis. ...
Introduced in the US in 1990. clozapine was initially linked or ‘bundled’ with a proprietary drug monitoring and distribution system, the Clozaril® Patient Monitoring System (CPMS). This arrangement, unique in US pharmaceutical history, was held to be largely responsible for the high cost of...
Clozapine belongs to the second generation of antipsychotics (SGA) and was the first of these so-called atypical antipsychotic drugs without producing extrapyramidal-motor side effects. It is approved as a second-line therapy for treatment-resistant schizophrenia only with required regular hematological ...
JJ Layland,D Liew,DL Prior - 《Medical Journal of Australia》 被引量: 95发表: 2009年 Rapid clozapine dose titration and concomitant sodium valproate increase the risk of myocarditis with clozapine: a case-control study. Despite the implementation of cardiac monitoring guidelines, clozapine-induced ...
AUSTRALIACLOZAPINENEUTROPENIAAGRANULOCYTOSISNEUTROPHILSPATHOLOGICAL physiologyObjectives: This paper critiques the haematological monitoring guidelines for clozapine. It describes the history of clozapine, as well as the pathophysiology and epidemiology of clozapine-induced neutropenia (CIN) and a...
Despite the implementation of cardiac monitoring guidelines, clozapine-induced myocarditis continues to cause deaths in Australia, and the risk is a barrier to prescription of this effective drug for the treatment of schizophrenia. This study was designed to identify clinical and phenotypic risk factors...
The high incidence of adverse events should reinforce to clinicians the need for vigilant monitoring. Pediatric guidelines recommend clozapine for refractory schizophrenia but stress the critical need to ensure an accurate diagnosis. Limited data exist for the use of clozapine in pediatric patients with ...
monitoring and drug distribution is now permissible through alternative agencies. Under this new arrangement the acquisition cost of the drug ($US2.85 per 100mg tablet) has been separated from the monitoring cost (unspecified). This translates into an annual treatment cost (exclusive of monitoring) ...
Therapeutic drug monitoring (TDM) is well established as a robust approach to account for variability in drug exposure. It is performed by measuring an individual’s plasma drug concentration to assess whether this is within a recommended therapeutic concentration range, and this is then typically fo...