Because it is associated with severe and potentially fatal side effects (agranulocytosis), its use is restricted to refractory schizophrenia, and monitoring during therapy is required. Clozapine therapy is associated with serum aminotransferase elevations and in rare instances has been linked to ...
Whereas the dose of haloperidol that normalized the hyperactivity of Egr3À/À mice did not affect the locomotion of wild-type (WT) control animals, the dosage of clozapine required to normalize the activity of Egr3À/À mice profoundly suppressed the locomotor activity in their WT litter...
Screening and preventative strategies should be established and appropriate symptomatic treatment applied when required. Keywords: constipation; clozapine; treatment-resistant schizophrenia; adverse events; systematic review; meta-analysis 1. Introduction Antipsychotic medication is the mainstay of the treatment ...