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Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia that can be life-saving and life-altering. Because of a risk for agranulocytosis, registry-based prescribing with regular monitoring of neutrophil granulocytes is mandate
resulting in decreased effectiveness of VERSACLOZ. Tobacco smoke is a moderate inducer of CYP1A2. Strong CYP3A4 inducers include carbamazepine, phenytoin, St. John's wort, and rifampin. It may be necessary to increase the VERSACLOZ dose if used concomitantly with inducers...
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) have become a premier neuroscience research tool for enabling reversible manipulations of cellular activity following experimenter-controlled delivery of a DREADD-specific ligand. However, several DREADD ligands, e.g., clozapine-N-oxide (...
In addition, almost half of the sample (44.4%) had regularly used cocaine before starting the study follow-up (during which time, substance use was controlled by testing for the presence of toxic substances in urine samples collected at each monthly visit). Table 2 shows the results of our ...
Nine patients had a history of substance use. At the time of treatment combination, 3 patients were consuming cannabis only while 2 patients were consuming cannabis and cocaine. 3.2. Data relative to clozapine and LAI antipsychotic introduction (Table 1) The mean age at treatment combination ...
a functional role in the off-target effects of CNO administration remains to be determined, but it is worth nothing that CNO produced higher overall substitution for the clozapine stimulus in mice in the present study. It is plausible that the mouse-specific emergence of NDMC following CNO ...
azepam(internal standard, 250 g/ml) were prepared by dis- solving appropriate amount of pure substance in methanol. Working solutions were obtained by diluting the stock solu- tions with methanol. All the standard solutions were stored at −20 ◦ C. Plasma was spiked with stock solutions ...
The following adverse reactions have been identified during post-approval use of clozapine. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. ...
Currently, encapsulation of active compounds is a promising strategy in modern molecular pharmacology. Therefore, in the light of the above-described issues, encapsulation of clozapine, allowing its controlled release and delivery, can lead to an improvement of the therapeutic potential of the drug, ...