“Rarely, clozapine will cause a drop in the number of these white cells and it is important that this is detected early. The risk is higher when clozapine is first started, and after 18 weeks the frequency of blood tests can be reduced but you will need to have regular blood tests for...
Weekly blood tests are required for the first 6 months. An ANC is required every 2 weeks for the next 6 months if an acceptable ANC is maintained during the first 6 months of continuous therapy. An ANC is required once every 4 weeks thereafter if an acceptable ANC is maintained during the...
HUMAN EXPOSURE AND TOXICITY: The most frequent adverse effects of clozapine involve the central and autonomic nervous systems (e.g., drowsiness or sedation, hypersalivation) and the cardiovascular system (e.g., tachycardia, hypotension). While the frequency and severity of some adverse effects (e...
The following adverse reactions have been identified during post-approval use of clozapine. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Central Ne...
The frequency of seizures goes up as the dose of the drug is increased. Patients who experience seizures on clozapine should usually have the drug discontinued or the dose reduced. Neuroleptic malignant syndrome (NMS), a dangerous condition with high fever, muscular rigidity, rapid pulse, sweating...
97,99–102 This has led to curtailed use of the drug and the requirement for regular blood tests to monitor white blood cell counts in patients treated with clozapine.96,97 Because of clozapine's effectiveness, further research on the drug proceeded in two complementary areas. The first was ...
If clozapine is discontinued because of moderate to severe neutropenia, monitor ANC according to neutropenia monitoring recommendations. Monitor ANC if fever occurs during the 2 weeks after clozapine discontinuance.See Tables 1and 2 for ANC monitoring frequency and treatment recommendations based on ANC ...
relative differences in the dosage of clozapine vs the comparison antipsychotic drug, differences in the use of concomitant medications, or differences in the frequency of clinical contact (usually increased in patients treated with clozapine because blood monitoring to detect potential emergence of agranu...
The woman, who had a history of bipolar disorder, received clozapine at a dosage increased from 50mg to 250mg [ route and frequency of administration not stated ] over a 7-day period. After 10聽days of clozapine treatment, she suddenly developed a fast rising fever, neck stiffness, and ...
In 2005 FDA approved criteria to allow reduced blood monitoring frequency.[8] Indications Clozapine is used principally in treating treatment-resistant schizophrenia,[9] a term used for the failure of symptoms to respond satisfactorily to at least two different antipsychotics;[10] It clearly has ...