Despite the effectiveness of clozapine, there is a reluctance to use it because of: patient concerns, e.g., blood test frequency; physician concerns, e.g., side effect management; system issues e.g., registration and monitoring; and medication use complexity e.g., dosing and titration (4)...
reassess bowel function frequently with careful attention to any changes in the frequency or character of bowel movements, as well as signs and symptoms of complications
However, there are legal restrictionson its use because of a relatively high frequency of agranulocytosis.As a rule, two other antipsychotics are tried beforerecourse to therapy with clozapine. Clozapine is metabolized preferentially by CYP3A4 into demethylated, hydroxylated,and N-oxide derivatives ...
monitoring frequency may be reduced to every 2 weeks for the next 6 months. If the ANC remains equal to or greater than 1500/μL for the second 6 months of continuous therapy
with anxiolytic agents94. Previously, it has been established that atypical antipsychotics, such as clozapine and olanzapine do possess anxiolytic effects95. The results of the study showed an increase in rearing frequency and number in the clozapine-treated group, thus suggesting its anxiolytic ...
R. Decreased dopamine in striatum and difficult locomotor recovery from MPTP insult after exposure to radiofrequency electromagnetic fields. Sci. Rep. 9, 1201 (2019). Article PubMed PubMed Central ADS CAS Google Scholar Mignini, F. et al. Dopamine receptor immunohistochemistry in the rat ...
(Supplementary Figure 4). Owing to the relatively small case sample size in our study we did not apply a frequency filter to variants in this analysis. Single variant association was conducted using logistic regression in PLINK with the first 10 principal components included as covariates. Adaptive...
However, there are legal restrictionson its use because of a relatively high frequency of agranulocytosis.As a rule, two other antipsychotics are tried beforerecourse to therapy with clozapine. Clozapine is metabolized preferentially by CYP3A4 into demethylated, hydroxylated,and N-oxide derivatives ...
reassess bowel function frequently with careful attention to any changes in the frequency or character of bowel movements, as well as signs and symptoms of complications of hypomotility (e.g., nausea, vomiting, abdominal distension, abdominal pain). If constipation or gastrointestinal hypomotility are...
μL for the first 6 months of treatment, monitoring frequency may be reduced to every 2 weeks for the next 6 months. If the ANC remains equal to or greater than 1500/μL for the second 6 months of continuous therapy, ANC monitoring frequency may be reduced to once every 4 weeks ...