BLACK box warningsANTIPSYCHOTIC agentsDOSE-effect relationship in pharmacologyGASTROINTESTINAL diseasesClozapine is the preferred antipsychotic for treatment-resistant schizophrenia, but has significant adverse effects, including gastrointestinal hypomotility or 'slow gut', which may result in severe c...
Clozapine (CAS NO.5786-21-0) also carries black box warnings for seizures, myocarditis, and "other adverse cardiovascular and respiratory effects."?Slow titration of dosing may also decrease the risk for orthostatic hypotension and other adverse cardiovascular side effects. It?may have a synergistic...
Clozapine carries five FDA black box warnings.Agranulocytosisis most likely in the first 3 months of treatment. The incidence in theabsenceof monitoring is as high as 1% to 2%; however, strict adherence to monitoring reduces the incidence to less than 0.5%.99Treatment should not be initiated ...
bradycardia, and syncope [seeWARNINGS AND PRECAUTIONS]. If that dose is well-tolerated, the dose may be increased to the previously therapeutic dose more quickly
The FDA also requires clozapine to carry five black box warnings for agranulocytosis, seizures, myocarditis, for "other adverse cardiovascular and respiratory effects", and for "increased mortality in elderly patients with dementia-related psychosis." 展开 关键词:...
Clozaril (clozapine) is a prescription antipsychotic medicine used to treat schizophrenia. Learn side effects, dosage, drug interactions, warnings, patient labeling, reviews, and more.
documented Benign Ethnic Neutropenia (BEN). During treatment, patients must have regular ANC monitoring. Advise patients to immediately report symptoms consistent with severe neutropenia or infection (e.g., fever, weakness, lethargy, or sore throat) [seeDOSAGE AND ADMINISTRATIONandWARNINGS ANDPRECAUTIONS...
documented Benign Ethnic Neutropenia (BEN). During treatment, patients must have regular ANC monitoring. Advise patients to immediately report symptoms consistent with severe neutropenia or infection (e.g., fever, weakness, lethargy, or sore throat) [seeDOSAGE AND ADMINISTRATIONandWARNINGS ANDPRECAUTIONS...