White blood cell (WBC) counts and differentials were recorded in a specific form to watch for any hematologic toxicity. The hematologic toxicities included in this report are: eosinophilia, thrombocytopenia, lymphocytopenia, and agranulocytosis/neutropenia/leukopenia combined.Complete WBC count.During the...
Conclusion:Hematologic side effects are frequently induced by the atypical antipsychotic clozapine. Next to agranulocytosis, a progressive and potentially lethal hematologic adverse effect, most of the WBC disorders are transient and appear to be harmless. 展开 ...
remind the patients to seek medical treatment immediately when infection or fever occurs. When there is an infection or WBC is less than 3.5 × 109/L or be much lower compared to the initial measured index, the white blood cell count should be reviewed immediately. If the absolute value of...
These programs function to notify the care provider of any significant drop in WBC/neutrophil count, or if there is a drop below a threshold level. Patients who enter the "Red" zone (WBC<2x109/L or ANC<1.5x109/L) should normally not be re-challenged. Clozapine induced myocarditis is a...
His laboratory testing revealed a white blood cell (WBC) count of 300/mm3, neutrophil count of 0/mm3, platelet (PLT) count of 186,000/mm3, hemoglobin (Hb) of 11.6 g/dL, glucose of 111 mg/dL, urea of 60 mg/dL, creatinine of 1.3 mg/dL, alanine transaminase (ALT) of 13 IU/L, ...
The Clozaril Patient Management System (CPMS) has been developed to provide a 100% fail-safe system for monitoring white blood cell counts (WBCs) in patien... B Bastani,LD Alphs,HY Meltzer - 《Psychopharmacology》 被引量: 684发表: 1989年 Is there a relationship between clozapine and obse...
Four patients affected by severe Parkinson's disease developed leucopenia (900–1200 WBC) during treatment of psychosis (3) or untreatable insomnia (1) wit... M Onofrj,A Thomas,L Bonanni,... - 《Neurological Sciences》 被引量: 11发表: 2000年 ...
Clozapine (CZP), a dibenzodiazepine atypical antipsychot- ic drug, was introduced for treatment of schizophrenia in Europe in 1971, rapidly gaining popularity due to its efficacy and virtual absence of extrapyramidal side effects [2]. However, its propensity to cause neutropenia and agranulocy- ...
(WBC) count. The ANC may also be calculated using the following formula:ANC equals the Total WBC count multiplied by the total percentage of neutrophils obtained from the differential (neutrophil “segs” plus neutrophil “bands”).Other granulocytes (basophils and eosinophils) contribute minimally ...
(WBC) count. The ANC may also be calculated using the following formula: ANCequals the Total WBC count multiplied by the total percentage of neutrophils obtained from the differential (neutrophil “segs” plus neutrophil “bands”).Other granulocytes (basophils and eosinophils) contribute minimally ...