Characterization of chronic lymphocytic leukemia (CLL) cells with low density of surface membrane bound immunoglobulins (smIg)CLLLow density smIgDifferentiationThe study consists of 6 CLL patients with leukemic blood lymphocytes lacking T-cell characteristics and with smIg on only a very small fraction ...
Chronic lymphocytic leukemia (CLL), the most frequent type of leukemia in western countries, is characterized by the progressive accumulation in blood, bone marrow and lymphoid tissues of monoclonal B lymphocytes with a characteristic immunophenotype. Despite advances in therapy and improved outcome, in ...
The nucleolar organizer regions (NORs) activity and the frequency of satellite associations (SA) in peripheral blood lymphocytes from patients with two chronic lymphoproliferative disorders were studied: 10 cases with B-cell chronic lymphocytic leukemia (B-CLL) and 10 with mycosis fungoides (MF). Thi...
Chronic lymphocytic leukemia (CLL)is a lymphoproliferative disordercharacterizedby the progressive accumulation of monoclonal lymphocytes with a distinctive immunophenotype in peripheral blood, bone marrow, and lymph nodes. It is the mostcommontype of leukemia in Western populations. Immune dysregulationis com...
T lymphocyte subpopulations in chronic lymphocytic leukemia of B cell type in relation to immunoglobulin isotype(s) on the leukemic clone and to clinical f... Total blood T lymphocytes and subpopulations (OKT4+ and OKT8 + cells) were studied in 59 patients with B cell chronic lymphocytic leuk...
Inferring a temporal gene network from a crucial signaling pathway in leukemic cells is a leading problem in oncology. We built a temporal transcriptional network of B-cell receptor (BCR) crosslinking in CLL and healthy B-cells, a critical step to understand the dynamics of BCR gene expression...
Targeting Notch signaling has emerged as a promising therapeutic strategy for chronic lymphocytic leukemia (CLL), particularly in NOTCH1-mutated patients. We provide first evidence that the Notch ligand DLL4 is a potent stimulator of Notch signaling in N
作者: LL Cll 摘要: Chronic lymphocytic leukaemia (CLL), the most frequent adult leukaemia in western countries is a clonal haematopoietic disorder with proliferation and accumulation of small lymphocytes of B lineage (1-3). Since the median age at diagnosis is 65 years, in many收藏...
The pathogenesis of B-cell chronic lymphocytic leukemia (CLL) and the mechanisms regulating the growth, survival, and expansion of the leukemic clone are still largely unknown, but there is growing evidence of the important role played by cytokine networ
A Combination of Cytokines Rescues Highly Purified Leukemic CLL B-Cells from Spontaneous Apoptosis In Vitro B-chronic lymphocytic leukemia (B-CLL), the most common human leukemia, is characterized by predominantly non-dividing malignant mature CD5+ B lymphocytes ... G Hussein,OH Hakim,D Gandhi,....