DACOGENSPACE3：clinicaltrials 赵婧华XJPMA2009-06-01 主要内容 化学结构产品信息临床试验 关键信息 作用机制 去甲基化药物 x 作用机制独特胞嘧啶类似物（连接了脱氧核糖）嵌入DNA与NMET不可逆结合逆转DNA过度甲基化状态达到治疗MDS目的 地西他滨 Santinietal.AnnInternMed2001;134:573 主要内容 化学结构产品信息临床试验...
在活体外的代谢研究表明地西他滨不是人类肝脏细胞色素P450酶的作用底物。由于血浆结合可忽略不计(<1%),因此与其他高血浆蛋白结合力药物的相互作用不太可能。化学结构产品规格临床试验关键信息主要内容 MDS治疗新药Dac space 3- clinical trials-090601-D0007 来自淘豆网www.taodocs.com转载请标明出处.猜你喜欢...
作者: $亚盛医药-B(06855)$APG-2575治疗一线MDS大三期注册临床在clinicaltrials登记了,试验代号GLORA-4,整个临床入组规模464人,临床方案是APG-2575+AZA对照AZA,临床终点是OS,主要完工时间是2029年6月。由于V药在MDS上由于毒性和剂量问题,大概率不会被FDA批准该适应症上市,所以该临床试验对于APG-2575非常重要,凭借...
Clinical Trials of Epigenetic Modifiers in the Treatment of Myelodysplastic SyndromeMyeloid malignancies, including acute myeloid leukemia (AML) and its precursor lesion myelodysplastic syndrome (MDS), are the result of bone marrow failure due to aberrant or arrested terminal differentiation. The prominent...
Early trials targeting the inflammasome to reduce inflammation integral to MDS and impaired erythropoiesis show promise. The anti-inflammatory agent canakinumab decreased a biomarker of inflammation but clinical responses are not yet seen. Further inflammation-directed trials are awaited to determine if targ...
Two-Stage Adaptive Design for Clinical Trials with Survival Data In long-term clinical trials we often need to monitor the patients enrollment, compliance, and treatment effect during the study. In this paper we take the... G Li,WJ Shih,Y Wang - 《Journal of Biopharmaceutical Statistics》 被...
1,2 Since 2011, trials investigating TIL therapies have continued to grow in number, with the majority of studies evaluating treatment of melanoma, non–small cell lung cancer (NSCLC), ovarian cancer, and head and neck cancer.3 TIL therapy involves harvesting infiltrated lymphocytes from tumors, ...
A comparison of the incidence of the myelodysplastic syndrome and acute myeloid leukaemia following melphalan and cyclophosphamide treatment for myelomatosis Twelve of 648 patients in the Medical Research Council's first two trials in myelomatosis have developed myelodysplasia or acute leukaemia. This co...
The panel discusses the use of composite end points, such as graft-vs-host disease–free, relapse-free survival (GRFS) and chronic graft-vs-host disease–free, relapse-free survival (CRFS), in a series of Blood and Marrow Transplant Clinical Trials Network (BMT CTN) trials. These end poi...
Meanwhile, a pair of failed trials for Novartis' Ilaris in non-small call lung cancer—one in newly diagnosed patients as an add-on to treatment with Merck & Co.'s Keytruda plus chemo and one alongside chemo as a second- or third-line option—punctured hopes of another sizable new revenue...