DACOGENSPACE3：clinicaltrials 赵婧华XJPMA2009-06-01 主要内容 化学结构产品信息临床试验 关键信息 作用机制 去甲基化药物 x 作用机制独特胞嘧啶类似物（连接了脱氧核糖）嵌入DNA与NMET不可逆结合逆转DNA过度甲基化状态达到治疗MDS目的 地西他滨 Santinietal.AnnInternMed2001;134:573 主要内容 化学结构产品信息临床试验...
作者: $亚盛医药-B(06855)$APG-2575治疗一线MDS大三期注册临床在clinicaltrials登记了,试验代号GLORA-4,整个临床入组规模464人,临床方案是APG-2575+AZA对照AZA,临床终点是OS,主要完工时间是2029年6月。由于V药在MDS上由于毒性和剂量问题,大概率不会被FDA批准该适应症上市,所以该临床试验对于APG-2575非常重要,凭借...
DACOGEN SPACE 3 : clinical trials赵婧华XJP MA 2009-06-01化学结构产品信息临床试验关键信息主要内容去甲基化药物作用机制地西他滨Santini et al. Ann Intern Med 2001;134:573x作用机制独特胞嘧啶类似物(连接了脱氧核糖)嵌入DNA与NMET不可逆结合逆转DNA过度甲基化状态达到治疗MDS目的稀释后应在15分钟内进行给药。
The myelodysplastic syndromes (MDS) are a heterogeneous spectrum of disorders requiring selective therapy based on patients' specific clinical features, predominantly their prognostic subgroups, age and performance status. Guidelines for management of patients with MDS have been generated by a number of ...
Early trials targeting the inflammasome to reduce inflammation integral to MDS and impaired erythropoiesis show promise. The anti-inflammatory agent canakinumab decreased a biomarker of inflammation but clinical responses are not yet seen. Further inflammation-directed trials are awaited to determine if targ...
Phase 1 testing of ezatiostat, a glutathione-S transferase P1-1 inhibitor, for thetreatment of myelodysplastic syndrome (MDS) was conducted in a multidose-escalation study. Patients received 10 dose levels (200, 400, 1000, 1400, 2000,2400, 3000, 4000, 5000 and 6000 mg) of ezatiostat table...
不过,最近的一项分析指出,细胞和基因疗法临床试验在FDA临床搁置总数中占比高达40%,而它们在http://ClinicalTrials.gov上公示的临床试验中占比仅2%。虽然这种不平衡可能部分反映了细胞和基因疗法领域科学的新颖性,以及许多细胞和基因疗法产品是“first in class”的事实,但搁置率似乎不成比例。如果没有其他原因,我们...
不过,最近的一项分析指出,细胞和基因疗法临床试验在FDA临床搁置总数中占比高达40%,而它们在ClinicalTrials.gov上公示的临床试验中占比仅2%。虽然这种不平衡可能部分反映了细胞和基因疗法领域科学的新颖性,以及许多细胞和基因疗法产品是“first in class”...
Novartis is looking to ligelizumab to defend the franchise, but with two phase 3 trials (PEARL 1 and PEARL 2) missing the mark, that hope has started to fade. CSU affects around 1% of the world's population and, in severe cases, causes debilitating symptoms that can last for weeks at...
Needed: clinical trials for older patients 来自 Semantic Scholar 喜欢 0 阅读量: 34 作者: BJ Kennedy 摘要: PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from Pub...