However, overall, the general impression of the clinical investigators was that idursulfase-IT treatment was beneficial in some patients, having the potential to alter the course of MPS II disease, and with patients treated earlier (at a younger age or earlier in the disease process) ...
Many of the individuals who report efforts to become ex-gay feel that the efforts were helpful, and a small percentage feel the efforts were harmful. 展开 关键词: political campaigns political processes impression management social behavior DOI: 10.1037/0735-7028.33.3.242 ...
open-label, parallel-group clinical trial (CT) performed at the Ace Alzheimer Center Barcelona. The study consists of a cohort of individuals with MCI (GDS = 3) followed up for 12 months. Later, an extension of the study was approved, allowing for an additional follow-up period of 12...
Alzheimer disease (AD) represents a major global medical, social, and economic burden. The World Alzheimer Report 2022 revealed that more than 55 million people have AD or related conditions worldwide, and this number is projected to reach 82 million by 2030 and 138 million by 2050 [1]. Typ...
PGIC, patient global impression of change. Except where designated otherwise, denominator is 34 studies. ⁎ Some studies had more than one type of outcome. Secondary outcomes were also collected at high rates in most of the studies, given the effect of pain on other domains. The list of ...
Here, patients are asked to communicate their subjective pain impression. To enable comparability, several variations of the so-called pain rating scales have been introduced in the past. Their purpose is to provide a fixed setup to reliably express pain based on given anchors or a framework, ...
Efficacy was also assessed using the clinician-rated Clinical Global Impression Severity of illness (CGI-S) and Improvement (CGI-I) scales,24 specifically applied to agitation, and the NPI-NH.18 Safety was assessed via treatment-emergent adverse events (TEAEs), body weight, laboratory tests, ...
reported spirituality had significantly higher (and clinically significant) symptoms of psychological distress than moderately and highly spiritual females. The findings of the present study provide contrasting conclusions from previous work supporting a single factor solution for the DSES, encourage further ...
(≥50% reduction in score from baseline), HAMD-17 remission (score ≤7, which is widely adopted as criteria for remission using this clinician-rated scale of depressive symptoms48,49), and Clinical Global Impression Improvement (CGI-I) response (1 indicated very much improved or 2, much ...
In addition, the following assessments associated with efficacy were performed: completion of the UDysRS and MDS-UPDRS, review of completed PD home diaries, and recording of investigator notes relevant to the Clinician’s Global Impression of Change (CGIC) scale.22 During the first week of ...