Over the past decades, click-chemistry has attracted significant attention in the preparation of crosslinked-biopolymer based hydrogels for biomedical applications. The click hydrogels offer arious benefits, such as simple preparation methods, better physical stability, improved mechanical properties, ability ...
Click Chemistry with Polymers, Dendrimers, and Hydrogels for Drug Delivery During the last decades, great efforts have been devoted to design polymers for reducing the toxicity, increasing the absorption, and improving the release... Enrique,Lallana,Francisco,... - 《Pharmaceutical Research》 被引量...
Hydrogels are crosslinked polymeric materials that play a vital role in many biomedical areas such as drug delivery, sensor technology, and tissue engineering. Increasing demand of these materials for such advanced applications has necessitated the development of hydrogels with complex chemical compositions...
Alginate hydrogels are well-characterized, biologically inert materials that are used in many biomedical applications for the delivery of drugs, proteins, and cells. Unfortunately, canonical covalently crosslinked alginate hydrogels are formed using chemical strategies that can be biologically harmful due to...
Growing Applications of "Click Chemistry" for Bioconjugation in Contemporary Biomedical Research This update summarizes the growing application of "click" chemistry in diverse areas such as bioconjugation, drug discovery, materials science, and radioch... K Nwe,MW Brechbiel - 《Cancer Biotherapy & Ra...
TIC hydrogels have been widely utilized for numerous biomedical applications due to their simplicity and good biocompatibility. However, weak molecular interaction often makes them suffer from poor mechanical properties in the physiological environment. To address this issue, NIC hydrogels derived from the...
www.nature.com/scientificreports OPEN Click-crosslinkable and photodegradable gelatin hydrogels for cytocompatible optical received: 24 June 2015 accepted: 16 September 2015 Published: 09 October 2015 cell manipulation in natural environment Masato Tamura, Fumiki Yanagawa, Shinji Sugiura, Toshiyuki...
(IF) staining of the DNA/RNA damage markers indicated that they were almost co-localized with mitochondria when the cells were injured by HG. When treated with the cell supernatant of HUVEC-laden hydrogels, the DNA/RNA damage signals were reduced, particularly for the HUVECvegf165+-laden ...
Click chemistry for drug development and diverse chemical−biology applications. Chem. Rev. 113, 4905–4979 (2013). 25. DeForest, C. A. & Anseth, K. S. Cytocompatible click-based hydrogels with dynamically tunable properties through orthogonal photoconjugation and photocleavage reactions. Nat...
The thiol-yne reactions are similar to the thiol-ene reactions, but involve the reaction of a thiol with an alkyne to form a carbon-sulfur bond, with a new carbon-carbon triple bond formed in the process. These reactions can be used for building dendrimers, hydrogels, and ...