In the clinic setting, tissue plasminogen activator (tPA) and thrombectomy could restore blood flow of the occlusion region and improve the outcomes of IS patients; however, these therapies are restricted by a narrow time window. Although several preclinical trials have revealed ...
Each of these issues significantly restricts the practical use of hydrogel-based drug delivery therapies in the clinic. In this review, we focus on recent developments addressing three key clinically relevant issues regarding the use of hydrogels for drug delivery: facilitating the in vivo application...
Chondrocyte senescence plays a considerable role in the impaired integrity and function of the cartilage. The accumulation of senescent cells within joint tissue results in the dysfunction of articular cartilage homeostasis [34]. It is also involved in the overproduction of reactive oxygen species (ROS...
Advanced tools for the in situ treatment of articular cartilage lesions are attracting a growing interest in both surgery and bioengineering communities. The interest is particularly high concerning the delivery of cell-laden hydrogels. The tools currently available in the state-of-the-art hardly find...
(188Re) are used to selectively inject radioactive microspheres intra-arterially and cause radiation-induced cell necrosis [13]. According to the Barcelona Clinic Liver Cancer (BCLC) staging system, TACE is the first-line treatment for patients with intermediate stage HCC, including those with ...
his interest in biomaterial-based approaches to therapy in the eye. He recently completed his MD and PhD under the supervision of Shoichet and van der Kooy, and he'll be continuing his medical training as an ophthalmologist, hoping to apply some of his research insights in the clinic one ...
However, endogenous NO may not be sufficient in bacterial infected wounds. Therefore, choosing appropriate NO donor is particularly important for NO-based gas therapy. Sodium nitroprusside dihydrate (SNP) was the most frequently-used NO donor in the clinic. Upon exposure to visible light (390–780...
The fusion are affected by the the printing time between adjacent layers and cooling temperature If a clinic size is printed, the layer height Ter2r, oinr other word, different structures may cause different caused by collapse and fusion should be considered. fusion height. Here, we gave an ...
Compilation of the top interviews, articles, and news in the last year. Download a free copy The team made of scientists from the Terasaki Institute and Mayo Clinic performed various tests to determine the optimum tantalum particle size and quantity to use and their effect on the mechanical pr...
Self-assembling peptide scaffolds in the clinic ArticleOpen access17 February 2021 Viscoelastic behavior of chemically fueled supramolecular hydrogels under load and influence of reaction side products ArticleOpen access17 September 2021 Introduction