This technique appears particularly suited for research of diseases that are characterized by decreased cell replication and, in fact, cell death.However, the TUNEL technique can result in wide variations in the per- centage of apoptosis reported for diseases such as atherosclerosis, car- dio...
Poly(ADP-ribose) polymerase-1 (PARP-1), also designated PARP, is a nuclear DNA-binding zinc finger protein that influences DNA repair, DNA replication, modulation of chromatin structure, and apoptosis. In response to genotoxic stress, PARP-1 catalyzes th
Cleaved PARP Rabbit Monoclonal Antibody -20℃保存,Western一抗稀释液-20℃或4℃保存,一年有效。Western一抗稀释液优先推荐4℃保存,长期不使用可以考虑-20℃保存,但冻融可能会导致出现轻微的浑浊和少量不溶物。 注意事项: 如果本抗体用于Western blot (WB)、免疫荧光(IF)、免疫细胞化学(ICC)等实验,请注意回收使...
PARP,a 116 kDa nuclear poly (ADP-ribose) polymerase,is a highly conserved nuclear enzyme implicated in DNA repair and in the apoptosis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavage targets of
PARP-1 recognizes DNA strand interruptions and can complex with RNA and negatively regulate transcription. Actinomycin D- and etoposide-dependent induction of caspases mediates cleavage of PARP-1 into a p89 fragment that traverses into the cytoplasm. Apoptosis-inducing factor (AIF) translocation from ...
of ADP-ribose to a variety of nuclear protein acceptors. Proteolysis of PARP to its stable 85kDa fragment is an early marker of programmed cell death (apoptosis) and is mediated by the caspase CPP32 protein. Cleavage occurs between Adp216 and Gly217, a site in PARP conserved across species...
We have further shown that γH2AX and cleaved PARP-1 are applicable markers for apoptosis in the proliferative regions of the spheroids. However, the more intense and clear staining patterns of γH2AX suggests that this marker is preferable for quantification of apoptosis in spheroids and similar ...
9660 Apoptosis Marker: Cleaved Caspase-3 (Asp175) Western Detection Kit Antibody Sampler Kit 1 Kit CNY 5,832 9847 Methyl-Histone H3 Antibody Sampler Kit Antibody Sampler Kit 1 Kit CNY 4,835 9849 Phospho-Histone H3 (Mitotic Marker) Antibody Sampler Kit Antibody Sampler Kit 1 Kit CNY 4,264 ...
PARP (Cleaved)抗体,【背景资料】:PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apoptosis response of cells. This protein can be cleaved by
PARP (Cleaved)抗体,【背景资料】:PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apoptosis response of cells. This protein can be cleaved by