The formation of CCVs relies on heterotetrameric adaptor protein complexes, which physically connect clathrin with transmembrane cargo proteins29,30,31. The most prominent adaptor protein complex that is involved in cargo shuttling from the TGN to endolysosomes is AP-1, which consists of the four s...
Distinct and redundant functions of μ1 me- dium chains of the AP-1 clathrin-associated protein complex in the nematode Caenorhabditis elegans. Mol Biol Cell 2000, 11: 2743-2756Molecular genetic analysis of apm-2 and aps-2, genes encoding the medium and small chains ...
Finally, we demonstrate that the TCR zeta/CD3 complex (but not CD28) also binds to AP-1 and AP-2 complexes, thus providing a possible link between these two receptors in the regulation of T cell function. 展开 关键词: Animals Humans Mice Lysosomes Intracellular Fluid T-Lymphocytes, Cytotoxic...
The UIM region of epsin 1 associates directly with polyubiquitin chains but has extremely poor affinity for monoubiquitin. Polyubiquitin binding is retained when epsin synchronously associates with phosphoinositides, the AP-2 adaptor complex and clathrin. The enrichment of epsin within clathrin-coated ...
In addition, in a previous study using the yeast two-hybrid system, we were able to demonstrate interactions between the two large subunits of the AP-1 and...Aguilar RC , Ohno H , Roche KW , Bonifacino JS . 1997 . Functional domain mapping of the clathrin-associated adaptor medium ...
The UIM region of epsin 1 associates directly with polyubiquitin chains but has extremely poor affinity for monoubiquitin. Polyubiquitin binding is retained when epsin synchronously associates with phosphoinositides, the AP-2 adaptor complex and clathrin. The enrichment of epsin within clathrin-coated ...
In addition, in a previous study using the yeast two-hybrid system, we were able to demonstrate interactions between the two large subunits of the AP-1 and...
The two other Drosophila members of the medium-chain family of clathrin-associated protein complexes, AP47 and μ3, have also been identified and mapped to 85D20–D27 and 6E1–E4, respectively.doi:10.1016/S0378-1119(99)00142-0Yong Q. Zhang...
Characterization of the sequence coding for the clathrin coat assembly protein AP17 (sigma2) associated with the plasma membrane from Zea mays and constitutive expression of its gene. Gene. 1998 Feb 16;208(1):67-72.Roca, R., Stiefel, V., Puigdome`nech, P., 1998. Characterization of the...