The formation of CCVs relies on heterotetrameric adaptor protein complexes, which physically connect clathrin with transmembrane cargo proteins29,30,31. The most prominent adaptor protein complex that is involved in cargo shuttling from the TGN to endolysosomes is AP-1, which consists of the four s...
(2000). Distinct and redundant functions of mu1 medium chains of the AP-1 clathrin-associated protein complex in the nematode Caenorhabditis elegans. Mol. Biol. Cell 11, 2743-2756.Shim, J., et al., “Distinct and Redundant Functions of μ1 Medium Chains of the AP...
Finally, we demonstrate that the TCR zeta/CD3 complex (but not CD28) also binds to AP-1 and AP-2 complexes, thus providing a possible link between these two receptors in the regulation of T cell function. 展开 关键词: Animals Humans Mice Lysosomes Intracellular Fluid T-Lymphocytes, Cytotoxic...
The UIM region of epsin 1 associates directly with polyubiquitin chains but has extremely poor affinity for monoubiquitin. Polyubiquitin binding is retained when epsin synchronously associates with phosphoinositides, the AP-2 adaptor complex and clathrin. The enrichment of epsin within clathrin-coated ...
The UIM region of epsin 1 associates directly with polyubiquitin chains but has extremely poor affinity for monoubiquitin. Polyubiquitin binding is retained when epsin synchronously associates with phosphoinositides, the AP-2 adaptor complex and clathrin. The enrichment of epsin within clathrin-coated ...
In addition, in a previous study using the yeast two-hybrid system, we were able to demonstrate interactions between the two large subunits of the AP-1 and...
To investigate this possibility, liposomes were used to deliver to intact rat alveolar macrophages (AMs): 1) Abs to clathrin, clathrin adaptor AP-2, and hsc70, and 2) amantadine. Phagocytosis was assayed by fluorometric and colorimetric techniques. Liposome-delivered Abs to clathrin and AP-2 ...