31. Accordingly, pSTING colocalized with AP-1 at the TGN, and STING robustly bound the γ and σ1 subunits of AP-1 after activation (Fig.2a,band Extended Data Fig.4a). STING associated with AP-1 in response to diverse cellular activators of STING, ...
AP-1B is expressed only in epithelia and mediates the polarized targeting of memb... F Herrero - 《Journal of Cell Biology》 被引量: 152发表: 2003年 Genomic structure and chromosome mapping of the genes encoding clathrin-associated adaptor medium chains μ1A (Ap1m1) and μ1B (Ap1m2). ...
Without the assistance of AAGAB, AP2 subunits fail to form the adaptor complex, leading to their degradation. The function of AAGAB is abrogated by a mutation that causes punctate palmoplantar keratoderma type 1 (PPKP1), a human skin disease. Since other multimeric trafficking adaptors operate in...
For lipid membranes, it contains a term for bending and a term for stretching, both taking the form of the energy associated with a harmonic spring: a constant called the modulus or rigidity, multiplied by the shape change to the square. Thus, bending energy is the bending rigidity ...
Another player that is closely connected to theHCV core proteinis the vesicle-associated membraneprotein 1(VAMP1). VAMP1 is considered a v-(vesicular)-SNARE (solubleN-ethylmaleimide-sensitive factor attachment protein receptor), which is located in the membrane of vesicles that bind to t-(target...
Tyrosine Phosphorylation Controls Internalization of CTLA-4 by Regulating Its Interaction with Clathrin-Associated Adaptor Complex AP-2 Immunity. 1997 May;6(5):583-9. Research Support, Non-U.S. Gov't T Shiratori,S Miyatake,H Ohno,... - 《Immunity》 被引量: 526发表: 1997年 Characterization...
We now find that most of this additional RAB-5 is associated with early endosomes that are still able to undergo homotypic membrane fusion (see Figure S1A and Movie S1 available online). The block of the transition from early to late endosomes and the continued activation of RAB-5 is a ...
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As shown in Figure 2C (inset), the purified VLDL particles do indeed contain apoB100 (Mr, 512 kD) and apoE (Mr, 34 kD) indicating that they have the proper associated proteins necessary for efficient receptor binding and internalization. When GM00701 cells were incubated at 4°C with ...
de Melker, A. A., van der Horst, G., Calafat, J., Jansen, H. & Borst, J. c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route.J. Cell Sci.114, 2167–2178 (2001). ...