Prostaglandins form a category of lipids that are also termed eicosanoids. These molecules are acquired from arachidonic acid. The varied biological activity in these molecules is due to their contrasting structure. Answer and Explanation:1 Prostaglandins can be classified as saturated, monosaturated, mo...
the known Lipinski chemical roles (e.g. molecular weight less than 500). They also included receptor-based descriptors (e.g. amino acid sequence information) along with Lipinski-ligand-based descriptors, such that the target variable will be binary (1 if there’s an interaction, 0 otherwise)....
The molecular recognition of the RORγ nuclear hormone receptor (NHR) ligand-binding domain (LBD) has been extensively studied with numerous X-ray crystal structures. However, the picture afforded by these complexes is static and does not fully explain t
For example, depending upon their chemical structure and properties, these known endogenous ligands for GPCRs have been categorized in seven types, namely, amine, amino acid, carboxylic acid, lipid, peptide, nucleoside and nucleotide. Similarly, the ions transported by the ion channel proteins and ...
The results found here were largely confirmed concurrently by analyses of microarray hybridizations [17, 33]. Among the enriched molecular functions shared between libraries, we found enzymes related to the β-lactam pathway (e.g. N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase), ...
The model reported overall classification accuracy of 94.87% for the first level, 87.7% for the second, and 84.25% for the bottom level. Our results compare very well with existing methods, and in many cases report better performance. Using feature selection methods, we have shown the ...
We have named the tool RSpred for RIFIN and STEVOR predictor. Figure 1 Schematic representation of RIFIN and STEVOR proteins. Schematic representation of A-RIFIN, B-RIFIN and STEVOR proteins (not to scale). Aa: amino acid; Indel: insertion/deletion; SP?: potential signal peptide; V1: ...
the structure-function relationship of proteins: (i) the lack of a formal definition of what critical residues are and (ii) the lack of a systematic evaluation of methods and protein structure features. To address this problem, here we introduce an index to quantify the protein-function ...
The results of this study can help safety managers to develop risk management strategies. Keywords: accident reports; text classification; deep learning; CNN; BiLSTM 1. Introduction Workplace health and safety is a significant concern in all countries [1] because there are more than 2.78 million...