Question: Classify the following prostaglandin. Prostaglandins: Prostaglandins form a category of lipids that are also termed eicosanoids. These molecules are acquired from arachidonic acid. The varied biological activity in these molecules is due to their contrasting structure. ...
In DTO, each of the four drug target families has two vocabulary files of gene and protein, respectively; other DTO-native categories were created as separate vocabulary files. Additional vocabulary files include quality, role, properties, and cell line classes and subclasses. A vocabulary file con...
Consider an enzyme containing an iron-sulfur cluster (which is very common among metalloenzymes) where the atoms of each type are arranged at the corners of a cube. Let us model an electron within this complex molecular system with a m...
the high attrition rate, even at the final stages of the drug development process, is a substantial risk factor for this industry pushing it toward adopting very different business
We also provide an analysis of one of the top ranked features, composition of Cysteine in enzyme sequences. 2. Materials and methods 2.1. Random forest Random forest is a classification algorithm developed by Leo Breiman that uses an ensemble of classification trees [14]. Each of the ...
Although these two protein families are different, they have more similarity to each other than to any other proteins described to date. As a result, they have been grouped together in one Pfam domain. However, a recent study has described the sub-division of the RIFIN protein family into ...
Analyzing the amino acid sequence of an intrinsically disordered protein (IDP) in an evolutionary context can yield novel insights on the functional role of disordered regions and sequence element(s). However, in the case of many IDPs, the lack of evolutionary conservation of the primary sequence...
The nature of the compounds ranged from pesticides to hormone mimickers to potential anti-cancer drugs, with a common characteristic molecular structure or 'scaffold' for each family. Eight out of twelve different molecular families showed correlation between scaffold and gene expression profile over ...
residues play in protein function, it is expected that different attributes of protein structure and multiple algorithms may be required to predict these residues; in such case, it may be anticipated the need to systematically test each of these factors in the structure-function relationship of ...