known as periodic fever syndromes. Since this original description, the focus has shifted considerably to the inclusion of complex multifactorial conditions with an autoinflammatory basis. Furthermore, the
As central mediators of innate and adaptive immune responses, T cells are critical orchestrators and effectors of the immune response. As such, several PIDs result from loss of or altered T cell function. PID-associated functional defects range from complete absence of T cell development to ...
Isolation of an Active Lv1 Gene from Cattle Indicates that Tripartite Motif Protein-Mediated Innate Immunity to Retroviral Infection Is Widespread among Ma... Lv1/TRIM5α (tripartite motif 5α) has recently emerged as an important factor influencing species-specific permissivity to retroviral infection...
Background The concept of innate immunity is well recognized within the spectrum of atherosclerosis, which is primarily dictated by macrophages. Although current insights to this process are largely based on murine models, there are fundamental differences in the atherosclerotic microenvironment and associat...
Epigenetics underpins the regulation of genes known to play a key role in the adaptive and innate immune system (AIIS). We developed a method, EpiNN, that leverages epigenetic data to detect AIIS-relevant genomic regions and used it to detect 2,765 putative AIIS loci. Experimental validation...
Innate immunity in the etiopathology of autoimmunity. Examines the relationship of the innate immune system to autoimmune disorders. Case of lupus, type 1 diabetes, multiple sclerosis and Crohn's disease; Inna... Carroll,Michael - 《Nature Immunology》 被引量: 49发表: 2001年 Adipokines and etio...
The presence of immune cells may reflect a distinct underlying biology of the tumor, as gene expression profiling and other assays have revealed the presence of a broad signature of inflammation. This signature includes evidence for innate immune activation, chemokines for innate and adaptive cell ...
Adaptive immune cells and innate immune cells in tumor microenvironment are contributor factors to tumor progression28. Great differences were detected in the infiltration scores of CD8 T cells, resting memory CD4 T cells, follicular helper T cells, regulatory T cells, gamma delta T cells, monocytes...
A method for determining improved innate immunity, disease resistance or performance in animals is disclosed. The method involves assays for a genetic diff... CK Tuggle,L Marklund,TJ Stabel,... - US 被引量: 46发表: 2003年 Observations on Vertical Variability in Groundwater Quality: Implications...
activated B cells may participate in anti-tumor immune response through different mechanisms, including secretion of antigen-specific antibodies, induction of innate immune cells (e.g., M1 tumor-associated macrophages), release of different cytokines (e.g., IL-6) and activation of complement cascade...